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Hokkaido University Collection of Scholarly and Academic Papers >
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Combination of alpha-Glycosyl-Isoquercitrin and Soybean Fiber Promotes Quercetin Bioavailability and Glucagon-like Peptide-1 Secretion and Improves Glucose Homeostasis in Rats Fed a High-Fat High-Sucrose Diet
| Title: | Combination of alpha-Glycosyl-Isoquercitrin and Soybean Fiber Promotes Quercetin Bioavailability and Glucagon-like Peptide-1 Secretion and Improves Glucose Homeostasis in Rats Fed a High-Fat High-Sucrose Diet |
| Authors: | Trakooncharoenvit, Aphichat Browse this author | | Hara, Hiroshi Browse this author →KAKEN DB | | Hira, Tohru Browse this author →KAKEN DB |
| Keywords: | diabetes | | diet-induced obesity | | fermentable fiber | | glucose tolerance |
| Issue Date: | 2-Jun-2021 |
| Publisher: | American Chemical Society |
| Journal Title: | Journal of Agricultural and Food Chemistry |
| Volume: | 69 |
| Issue: | 21 |
| Start Page: | 5907 |
| End Page: | 5916 |
| Publisher DOI: | 10.1021/acs.jafc.1c01388 |
| Abstract: | This study examined the effects of a combination of soybean fiber and alpha-glycosyl-isoquercitrin (AGIQ) on improving quercetin bioavailability and glucose metabolism in rats fed an obesogenic diet. For 9 weeks, rats were individually fed a control diet, a high-fat high-sucrose (H) diet, H with soybean fiber (HS), or with AGIQ (HQ), or with both (HSQ). Quercetin derivatives in plasma, feces, urine, and cecal content were quantified by high-performance liquid chromatography to assess the bioavailability of quercetin, and meal tolerance tests were performed to assess postprandial glycemia and glucagon-like peptide-1 (GLP-1) responses. The HSQ group had higher plasma quercetin levels than HQ. The postprandial glycemia was attenuated in the HSQ group when compared to the H group. The basal plasma GLP-1 concentrations positively correlated with plasma quercetin derivative concentrations. Hence, the combination of soybean fiber and AGIQ could be beneficial for reducing the risk of glucose intolerance, possibly involving enhanced quercetin bioavailability and GLP-1 secretion. |
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Agricultural and Food Chemistry, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jafc.1c01388 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/85655 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 比良 徹
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