| Title: | Experiment on endoscopic balloon dilation for esophageal stenosis after endoscopic submucosal dissection in pigs |
| Authors: | Kinowaki, Sayoko Browse this author |
| Shimizu, Yuichi Browse this author →KAKEN DB |
| Ono, Masayoshi Browse this author →KAKEN DB |
| ZiJian, Yang Browse this author |
| Tanaka, Ikko Browse this author |
| Shimoda, Yoshihiko Browse this author |
| Inoue, Masaki Browse this author |
| Ishikawa, Marin Browse this author |
| Yamamoto, Keiko Browse this author →KAKEN DB |
| Ono, Shoko Browse this author →KAKEN DB |
| Ohnishi, Shunsuke Browse this author |
| Sakamoto, Naoya Browse this author →KAKEN DB |
| Keywords: | Balloon dilation |
| Esophageal stenosis |
| ESD |
| Issue Date: | 1-Jun-2021 |
| Publisher: | Springer |
| Journal Title: | Journal of gastroenterology |
| Volume: | 56 |
| Issue: | 6 |
| Start Page: | 527 |
| End Page: | 536 |
| Publisher DOI: | 10.1007/s00535-021-01791-2 |
| Abstract: | Background and aim Endoscopic balloon dilation (EBD) is effective for esophageal stenosis caused by ESD. However, an efficient EBD method has not been established. We, therefore, conducted EBD experiments on porcine esophageal stenosis models. Methods Study 1: in dilation models (day 22 after ESD), the thickness of the outer muscle layer (as an index of the extension effect) and the area of muscle fiber bundle necrosis in the inner muscle layer (as an index of thermal damage) were evaluated. Study 2: in restenosis models (day 43 after ESD), the thickness of the fibrous plexus (as an index of restenosis) was evaluated. In total, 12 porcine models were created. Results Study 1: the thickness of the outer muscle layer was 1243 +/- 322 mu m in surrounding locations and it was 803 +/- 145 mu m beneath the laceration (p = 0.005). In cases of muscular layer injury, the area of necrosis was 15,500 +/- 10400 mu m(2) in surrounding locations and it was 40,200 +/- 12900 mu m(2) at the laceration site (p < 0.001). Study 2: the thickness of the fibrous plexus was 1359 +/- 196 mu m in surrounding locations and it was 1322 +/- 136 mu m(2) in the laceration scar site (p = 0.74). Conclusion Since thermal damage persists until the completion of stenosis, EBD in the initial stage should be carefully performed. An extension effect was observed only at the laceration site and it later returned to a status similar to that of surrounding locations. Additional intervention would be required for preventing restenosis. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in Journal of Gastroenterology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00535-021-01791-2. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/85680 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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