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Hokkaido University Collection of Scholarly and Academic Papers >
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Serum fatty acid-binding protein 5 is a significant factor in hepatocellular carcinoma progression independent of tissue expression level
| Title: | Serum fatty acid-binding protein 5 is a significant factor in hepatocellular carcinoma progression independent of tissue expression level |
| Authors: | Ohira, Masafumi Browse this author | | Yokoo, Hideki Browse this author | | Ogawa, Koji Browse this author →KAKEN DB | | Fukai, Moto Browse this author →KAKEN DB | | Kamiyama, Toshiya Browse this author →KAKEN DB | | Sakamoto, Naoya Browse this author →KAKEN DB | | Taketomi, Akinobu Browse this author →KAKEN DB |
| Issue Date: | Jun-2021 |
| Publisher: | Oxford University Press |
| Journal Title: | Carcinogenesis |
| Volume: | 42 |
| Issue: | 6 |
| Start Page: | 794 |
| End Page: | 803 |
| Publisher DOI: | 10.1093/carcin/bgab025 |
| Abstract: | Fatty acid-binding protein 5 (FABP5) is highly expressed in hepatocellular carcinoma (HCC) tissues and is related to HCC progression. In this study, we analyzed the potential of serum FABP5 (sFABP5) as a tumor marker in HCC and its clinical significance in HCC progression. We compared the sFABP5 concentration in patients with HCC (HCC group) with that of patients with hepatitis without HCC (hepatitis group). Moreover, we measured the FABP5 expression levels in resected HCC tissues (tFABP5) and analyzed their relationship with sFABP5. We also performed cell-based assays using FABP5 knockout and overexpressing HCC cell lines to analyze the effect of extrinsic FABP5 (exFABP5) on HCC cells. We showed that sFABP5 was not a useful tumor marker for HCC, as HCC and sFABP5 were not correlated. However, sFABP5 and tFABP5 significantly correlated with survival after surgery for HCC, while sFABP5 and tFABP5 were independent of each other. In cell-based assays, exFABP5 was taken up by HCC cell lines and positively affected cell survival under glucose-depleted conditions by complementing the endogenous FABP5 function. In conclusion, sFABP5 had a significant impact on HCC progression irrespective of tFABP5 by augmenting cell viability under glucose-depleted conditions. As tFABP5 and 5FABP5 are important factors that are independent of each other in HCC progression, both of them should be considered independently in improving the prognosis of patients with HCC. |
| Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in Carcinogenesis following peer review. The version of record Masafumi Ohira, Hideki Yokoo, Koji Ogawa, Moto Fukai, Toshiya Kamiyama, Naoya Sakamoto, Akinobu Taketomi, Serum fatty acid-binding protein 5 is a significant factor in hepatocellular carcinoma progression independent of tissue expression level, Carcinogenesis, Volume 42, Issue 6, June 2021, Pages 794–803 is available online at: https://doi.org/10.1093/carcin/bgab025. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/85683 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 大平 将史
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