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Behavioral characteristics of dopamine D-5 receptor knockout mice

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Title: Behavioral characteristics of dopamine D-5 receptor knockout mice
Authors: Sasamori, Hitomi Browse this author
Asakura, Toshiaki Browse this author
Sugiura, Chiaki Browse this author
Bouchekioua, Youcef Browse this author
Nishitani, Naoya Browse this author
Sato, Masaaki Browse this author
Yoshida, Takayuki Browse this author
Yamasaki, Miwako Browse this author
Terao, Akira Browse this author
Watanabe, Masahiko Browse this author →KAKEN DB
Ohmura, Yu Browse this author →KAKEN DB
Yoshioka, Mitsuhiro Browse this author →KAKEN DB
Issue Date: 10-Apr-2022
Publisher: Nature Portfolio
Journal Title: Scientific reports
Volume: 12
Issue: 1
Start Page: 6014
Publisher DOI: 10.1038/s41598-022-10013-5
Abstract: Major psychiatric disorders such as attention-deficit/hyperactivity disorder and schizophrenia are often accompanied by elevated impulsivity. However, anti-impulsive drug treatments are still limited. To explore a novel molecular target, we examined the role of dopamine D-5 receptors in impulse control using mice that completely lack D-5 receptors (D5KO mice). We also measured spontaneous activity and learning/memory ability because these deficits could confound the assessment of impulsivity. We found small but significant effects of D-5 receptor knockout on home cage activity only at specific times of the day. In addition, an analysis using the q-learning model revealed that D5KO mice displayed lower behavioral adjustment after impulsive actions. However, our results also showed that baseline impulsive actions and the effects of an anti-impulsive drug in D5KO mice were comparable to those in wild-type littermates. Moreover, unlike previous studies that used other D-5 receptor-deficient mouse lines, we did not observe reductions in locomotor activity, working memory deficits, or severe learning deficits in our line of D5KO mice. These findings demonstrate that D-5 receptors are dispensable for impulse control. Our results also indicate that time series analysis and detailed analysis of the learning process are necessary to clarify the behavioral functions of D-5 receptors.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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