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Behavioral characteristics of dopamine D-5 receptor knockout mice
| Title: | Behavioral characteristics of dopamine D-5 receptor knockout mice |
| Authors: | Sasamori, Hitomi Browse this author | | Asakura, Toshiaki Browse this author | | Sugiura, Chiaki Browse this author | | Bouchekioua, Youcef Browse this author | | Nishitani, Naoya Browse this author | | Sato, Masaaki Browse this author | | Yoshida, Takayuki Browse this author | | Yamasaki, Miwako Browse this author | | Terao, Akira Browse this author | | Watanabe, Masahiko Browse this author →KAKEN DB | | Ohmura, Yu Browse this author →KAKEN DB | | Yoshioka, Mitsuhiro Browse this author →KAKEN DB |
| Issue Date: | 10-Apr-2022 |
| Publisher: | Nature Portfolio |
| Journal Title: | Scientific reports |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 6014 |
| Publisher DOI: | 10.1038/s41598-022-10013-5 |
| Abstract: | Major psychiatric disorders such as attention-deficit/hyperactivity disorder and schizophrenia are often accompanied by elevated impulsivity. However, anti-impulsive drug treatments are still limited. To explore a novel molecular target, we examined the role of dopamine D-5 receptors in impulse control using mice that completely lack D-5 receptors (D5KO mice). We also measured spontaneous activity and learning/memory ability because these deficits could confound the assessment of impulsivity. We found small but significant effects of D-5 receptor knockout on home cage activity only at specific times of the day. In addition, an analysis using the q-learning model revealed that D5KO mice displayed lower behavioral adjustment after impulsive actions. However, our results also showed that baseline impulsive actions and the effects of an anti-impulsive drug in D5KO mice were comparable to those in wild-type littermates. Moreover, unlike previous studies that used other D-5 receptor-deficient mouse lines, we did not observe reductions in locomotor activity, working memory deficits, or severe learning deficits in our line of D5KO mice. These findings demonstrate that D-5 receptors are dispensable for impulse control. Our results also indicate that time series analysis and detailed analysis of the learning process are necessary to clarify the behavioral functions of D-5 receptors. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/85686 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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