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Changes in Magnetic Resonance Signal Fluctuation in Superior Sagittal Sinus : Deterioration of Arteriolar Vasomotor Function of Young Smokers

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Title: Changes in Magnetic Resonance Signal Fluctuation in Superior Sagittal Sinus : Deterioration of Arteriolar Vasomotor Function of Young Smokers
Authors: Tang, Minghui Browse this author →KAKEN DB
Kubota, Masaya Browse this author
Nitanda, Yusuke Browse this author
Yamamoto, Toru Browse this author
Keywords: MRI
venous blood
arteriolar vasomotor function
smoking
Issue Date: Apr-2022
Publisher: MDPI
Journal Title: Tomography
Volume: 8
Issue: 2
Start Page: 657
End Page: 666
Publisher DOI: 10.3390/tomography8020055
Abstract: (1) Cerebral arteriolar vasomotor function is vital for brain health and has been examined through CO2 inhalation or breath-holding, which are both challenging for patients. We have developed a non-invasive method to evaluate this function with magnetic resonance imaging (MRI) by utilizing respiration-induced natural changes in partial pressure of arterial CO2 (PaCO2). In this study, we applied this method for 20s to evaluate the chronic effect of a few years smoking on the cerebral arteriolar vasomotor function. (2) A single slice (five slice thicknesses: 15 mm to 7 mm) perpendicular to the superior sagittal sinus of was imaged successively for 45 s using spin-echo echo-planar imaging by 3T MRI for ten smokers (24.5 +/- 1.6 years) and ten non-smokers (24.3 +/- 1.4 years), respectively. The venous oxygenation fluctuation (Delta Y-r) caused by the respiration-induced changes of PaCO2, which reflects the arteriolar vasomotor function, was calculated from the time series MR signal changes of superior sagittal sinus. (3) The Delta Y-r values of the smokers (0.7 +/- 0.6) were significantly lower than those of the non-smokers (1.3 +/- 0.8) (p = 0.04). (4) Degeneration of the cerebral arteriolar vasomotor function due to chronic smoking (even after 20s) was demonstrated by our non-invasive MRI-based method.
Type: article
URI: http://hdl.handle.net/2115/85695
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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