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A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys
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| Title: | A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys |
| Other Titles: | 卵巣摘出ラットおよびサルにおけるテリパラチドの投与量および投与頻度の違いにより生じる、骨の層板構造および骨コラーゲンの直線性の変化の定量的解析 |
| Authors: | 佐藤, 孝紀 Browse this author |
| Keywords: | bone lamellarity | | collagen linearity | | multi-photon microscopy | | SHG (second harmonic generation) | | semi-automatic recognition | | teriparatide |
| Issue Date: | 24-Mar-2022 |
| Publisher: | Hokkaido University |
| Abstract: | The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is therefore essential to develop a quantitative analysis to evaluate the lamellarity of bone, which would especially be useful for the pharmacological evaluation of anti-osteoporotic drugs. This study applied a current system for the semi-automatic recognition of fluorescence signals to the analysis of un-decalcified bone sections from rat and monkey specimens treated with teriparatide (TPTD). Our analyses on bone formation pattern and collagen topology indicated that TPTD augmented bone lamellarity and bone collagen linearity, which were possibly associated with the recovery of collagen cross-linking, thus endowing bone rigidity. |
| Conffering University: | 北海道大学 |
| Degree Report Number: | 甲第15022号 |
| Degree Level: | 博士 |
| Degree Discipline: | 歯学 |
| Examination Committee Members: | (主査) 教授 飯村 忠浩, 教授 網塚 憲生, 教授 山本 恒之 |
| Degree Affiliation: | 歯学院（口腔医学専攻） |
| (Relation)isversionof: | Sato, Takanori et al. “A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys.” Microscopy (Oxford, England) vol. 70,6 (2021). | | https://doi.org/10.1093/jmicro/dfab020 |
| Type: | theses (doctoral) |
| URI: | http://hdl.handle.net/2115/86039 |
| Appears in Collections: | 課程博士 (Doctorate by way of Advanced Course) > 歯学院(Graduate School of Dental Medicine)
学位論文 (Theses) > 博士 （歯学）
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