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The interferon-β/STAT1 axis drives the collective invasion of skin squamous cell carcinoma with sealed intercellular spaces
| Title: | The interferon-β/STAT1 axis drives the collective invasion of skin squamous cell carcinoma with sealed intercellular spaces |
| Authors: | Kumagai, Yuji Browse this author | | Nio-Kobayashi, Junko Browse this author →KAKEN DB | | Ishihara, Seiichiro Browse this author →KAKEN DB | | Enomoto, Atsushi Browse this author →KAKEN DB | | Akiyama, Masashi Browse this author →KAKEN DB | | Ichihara, Ryosuke Browse this author | | Haga, Hisashi Browse this author →KAKEN DB |
| Issue Date: | 24-May-2022 |
| Publisher: | Springer Nature |
| Journal Title: | Oncogenesis |
| Volume: | 11 |
| Start Page: | 27 |
| Publisher DOI: | 10.1038/s41389-022-00403-9 |
| Abstract: | The process by which cancer cells invade as a cell cluster, known as collective invasion, is associated with metastasis and worse prognosis of cancer patients; therefore, inhibition of collective invasion is considered to improve cancer treatment. However, the cellular characteristics responsible for collective invasion remain largely unknown. Here, we successfully established subclones with various invasive potentials derived from human skin squamous carcinoma cells. The cell cluster of the highly invasive subclone had a hermetically sealed and narrow intercellular space. Interferon-beta was localized to the sealed intercellular spaces, leading to collective invasion via the activation of signal transducer and activator of transcription 1 (STAT1). On the other hand, interferon-beta was not localized to non-sealed and wide intercellular spaces of the cell cluster of low-invasive subclone with deficient STAT1 activity. In the mixed cell cluster of high- and low-invasive subclones, the high-invasive sub-clonal cells were located at the invasive front of the invasive protrusion, leading to collective invasion by the low-invasive sub-clonal cells. Tissue microarray analysis of human skin squamous cell carcinoma (SCC) also showed enrichment of STAT1 in the invasive front of SCCs. These findings indicate that the intercellular structure controls the potential for collective invasion via STAT1 regulation in SCC. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86069 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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