| Title: | Dietary supplementation with okara and Bacillus coagulans lilac-01 improves hepatic lipid accumulation induced by cholic acids in rats |
| Authors: | Lee, Yeonmi Browse this author |
| Tanaka, Yasutake Browse this author |
| Iwasaki, Wakana Browse this author |
| Yokoyama, Fumika Browse this author |
| Joe, Ga-Hyun Browse this author |
| Tsuji, Misaki Browse this author |
| Nose, Takuma Browse this author |
| Tada, Koji Browse this author |
| Hanai, Taketo Browse this author |
| Hori, Shota Browse this author |
| Shimizu, Hidehisa Browse this author |
| Minamida, Kimiko Browse this author |
| Miwa, Kazunori Browse this author |
| Ishizuka, Satoshi Browse this author →KAKEN DB |
| Keywords: | Symbiotic |
| Hepatic lipid accumulation |
| Cholic acid |
| Okara |
| Rats |
| Issue Date: | Mar-2022 |
| Publisher: | Elsevier |
| Journal Title: | Journal of functional foods |
| Volume: | 90 |
| Start Page: | 104991 |
| Publisher DOI: | 10.1016/j.jff.2022.104991 |
| Abstract: | A dietary symbiotic supplement of okara, a by-product of tofu manufacturing with Bacillus coagulans lilac-01 found to reduce secondary bile acid (BA) in a rat study and cholic acid (CA), a primary 12 alpha-hydroxylated (12 alpha OH) BA, induces lipid accumulation in rats. In this study, we investigated whether dietary supplementation of a synbiotic with okara and Bacillus coagulans lilac-01 improves CA-induced hepatic lipid accumulation. Male Wistar/ST rats (4 weeks old) were fed with or without CA-supplementation combined with the synbiotic for 2 weeks. The CA diet increased hepatic triglycerides and the synbiotic diet in combination with CA normalized liver triglyceride concentration accompanied by suppression of hepatic fatty acid synthase expression, enhancement of fecal triglyceride excretion, and increase in fecal non-12 alpha OH BA excretion. Dietary supplementation with the okara synbiotic ameliorated hepatic lipid accumulation probably by reducing de novo lipogenesis and enhancing fecal triglyceride excretion. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86083 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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