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Disruption of model-based decision making by silencing of serotonin neurons in the dorsal raphe nucleus

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Title: Disruption of model-based decision making by silencing of serotonin neurons in the dorsal raphe nucleus
Authors: Ohmura, Yu Browse this author →KAKEN DB
Iwami, Kentaro Browse this author
Chowdhury, Srikanta Browse this author
Sasamori, Hitomi Browse this author
Sugiura, Chiaki Browse this author
Bouchekioua, Youcef Browse this author
Nishitani, Naoya Browse this author
Yamanaka, Akihiro Browse this author
Yoshioka, Mitsuhiro Browse this author →KAKEN DB
Keywords: 5-HT
Issue Date: 7-Jun-2021
Publisher: Cell Press
Journal Title: Current biology
Volume: 31
Issue: 11
Start Page: 2446
End Page: 2454.e5
Publisher DOI: 10.1016/j.cub.2021.03.048
Abstract: Adaptingto changing environmentalconditions requires a prospective inferenceof future actionsandtheir consequences, a strategy alsoknownasmodel-baseddecisionmaking.(1-3) In stable environments, extensive experience of actions and their consequences leads to a shift fromamodel-based to amodel-free strategy, whereby behavioral selection is primarily governed by retrospective experiences of positive and negative outcomes. Human and animal studies, where subjects are required to speculate about implicit information and adjust behavioral responses overmultiple sessions, point to a role for the central serotonergic systeminmodel-based decision making.(4-8) However, to directly test a causal relationship between serotonergic activity and model-based decision making, phase-specific manipulation of serotonergic activity is needed in a one-shot test, where learning by trial and error is neutralized. Moreover, the serotonergic origin responsible for this effect is yet to be determined. Herein, we demonstrate that optogenetic silencing of serotonin neurons in the dorsal raphe nucleus, but not in the median raphe nucleus, disrupts model-based decision making in lithium-induced outcome devaluation tasks.(9-11) Our data indicate that the serotonergic behavioral effects are not due to increased locomotor activity, anxiolytic effects, or working memory deficits. Our findings provide insights into the neural mechanisms underlying neural weighting between model-free and model-based strategies.
Rights: © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大村 優

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