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Estradiol-induced immune suppression via prostaglandin E-2 during parturition in bovine leukemia virus-infected cattle
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Title: | Estradiol-induced immune suppression via prostaglandin E-2 during parturition in bovine leukemia virus-infected cattle |
Authors: | Sajiki, Yamato Browse this author | Konnai, Satoru Browse this author →KAKEN DB | Okagawa, Tomohiro Browse this author →KAKEN DB | Maekawa, Naoya Browse this author →KAKEN DB | Goto, Shinya Browse this author | Kohara, Junko Browse this author | Nitanai, Atsushi Browse this author | Takahashi, Hirofumi Browse this author | Kubota, Kentaro Browse this author | Takeda, Hiroshi Browse this author | Murata, Shiro Browse this author →KAKEN DB | Ohashi, Kazuhiko Browse this author →KAKEN DB |
Issue Date: | 9-Mar-2022 |
Publisher: | PLOS |
Journal Title: | PLoS ONE |
Volume: | 17 |
Issue: | 3 |
Start Page: | e0263660 |
Publisher DOI: | 10.1371/journal.pone.0263660 |
Abstract: | Immune suppression during pregnancy and parturition is considered a risk factor that is related to the progression of bovine chronic diseases, such as bovine leukosis, which is caused by bovine leukemia virus (BLV). Our previous studies have demonstrated that prostaglandin E-2 (PGE(2)) suppresses BLV-specific Th1 responses and contributes to the disease progression during BLV infection. Although PGE(2) reportedly plays important roles in the induction of parturition, PGE(2) involvement in immune suppression during parturition is unknown. To investigate its involvement, we analyzed PGE(2) kinetics and Th1 responses in BLV-infected pregnant cattle. PGE(2) concentrations in sera were increased, whereas IFN-gamma responses were decreased before delivery. PGE(2) is known to suppress Th1 immune responses in cattle. Thus, these data suggest that PGE(2) upregulation inhibits Th1 responses during parturition. We also found that estradiol was important for PGE(2) induction in pregnant cattle. In vitro analyses indicated that estradiol suppressed IFN-gamma production, at least in part, via PGE(2)/EP4 signaling. In vivo analyses showed that estradiol administration significantly influenced the induction of PGE(2) production and impaired Th1 responses. Our data suggest that estradiol-induced PGE(2) is involved in the suppression of Th1 responses during pregnancy and parturition in cattle, which could contribute to the progression of BLV infection. |
Rights: | https://creativecommons.org/licenses/by/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/86222 |
Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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