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Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation

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Title: Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
Authors: Nishida, Mutsumi Browse this author →KAKEN DB
Sugita, Junichi Browse this author
Takahashi, Shuichiro Browse this author
Iwai, Takahito Browse this author
Sato, Megumi Browse this author
Kudo, Yusuke Browse this author
Omotehara, Satomi Browse this author
Horie, Tatsunori Browse this author
Sakano, Ryosuke Browse this author
Shibuya, Hitoshi Browse this author
Yokota, Isao Browse this author →KAKEN DB
Iguchi, Akihiro Browse this author
Teshima, Takanori Browse this author →KAKEN DB
Keywords: Sinusoidal obstruction syndrome
Veno-occlusive disease
Color Doppler
Hematopoietic stem cell transplantation
Issue Date: Jul-2021
Publisher: Springer
Journal Title: International journal of hematology
Volume: 114
Issue: 1
Start Page: 94
End Page: 101
Publisher DOI: 10.1007/s12185-021-03137-3
Abstract: Hepatic sinusoidal obstruction syndrome (SOS)/veno-occlusive disease is a life-threatening complication after hematopoietic stem cell transplantation (HSCT). We previously reported the efficacy of the Hokkaido Ultrasonography (US)-based scoring system (HokUS-10) for US findings. To establish easier-to-use criteria, we retrospectively evaluated US findings from 441 patients, including 30 patients with SOS using the HokUS-10 scoring system. Using logistic regression analysis, we established the novel diagnostic criteria HokUS-6. In the presence of ascites, US diagnosis was made in the presence of two of the following 6 parameters: moderate amount of ascites, the appearance of a paraumbilical vein blood flow signal, gallbladder wall thickening, portal vein dilatation, portal vein velocity decrease, and hepatic artery resistive index increase. The AUC, sensitivity, and specificity of HokUS-6 were 0.974 (95% confidence interval 0.962-0.990), 95.2%, and 96.9%, respectively. The scores were significantly higher in patients with severe SOS than in those with non-severe SOS (p = 0.013). Furthermore, the scores before HSCT were significantly higher in patients who developed SOS than in controls (p = 0.001). The HokUS-6 is an easy and useful way to diagnose and identify the risk of SOS.
Rights: This is a post-peer-review, pre-copyedit version of an article published in International journal of hematology. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西田 睦

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