| Title: | Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation |
| Authors: | Nishida, Mutsumi Browse this author →KAKEN DB |
| Sugita, Junichi Browse this author |
| Takahashi, Shuichiro Browse this author |
| Iwai, Takahito Browse this author |
| Sato, Megumi Browse this author |
| Kudo, Yusuke Browse this author |
| Omotehara, Satomi Browse this author |
| Horie, Tatsunori Browse this author |
| Sakano, Ryosuke Browse this author |
| Shibuya, Hitoshi Browse this author |
| Yokota, Isao Browse this author →KAKEN DB |
| Iguchi, Akihiro Browse this author |
| Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | Sinusoidal obstruction syndrome |
| Veno-occlusive disease |
| Ultrasonography |
| Color Doppler |
| Hematopoietic stem cell transplantation |
| Issue Date: | Jul-2021 |
| Publisher: | Springer |
| Journal Title: | International journal of hematology |
| Volume: | 114 |
| Issue: | 1 |
| Start Page: | 94 |
| End Page: | 101 |
| Publisher DOI: | 10.1007/s12185-021-03137-3 |
| Abstract: | Hepatic sinusoidal obstruction syndrome (SOS)/veno-occlusive disease is a life-threatening complication after hematopoietic stem cell transplantation (HSCT). We previously reported the efficacy of the Hokkaido Ultrasonography (US)-based scoring system (HokUS-10) for US findings. To establish easier-to-use criteria, we retrospectively evaluated US findings from 441 patients, including 30 patients with SOS using the HokUS-10 scoring system. Using logistic regression analysis, we established the novel diagnostic criteria HokUS-6. In the presence of ascites, US diagnosis was made in the presence of two of the following 6 parameters: moderate amount of ascites, the appearance of a paraumbilical vein blood flow signal, gallbladder wall thickening, portal vein dilatation, portal vein velocity decrease, and hepatic artery resistive index increase. The AUC, sensitivity, and specificity of HokUS-6 were 0.974 (95% confidence interval 0.962-0.990), 95.2%, and 96.9%, respectively. The scores were significantly higher in patients with severe SOS than in those with non-severe SOS (p = 0.013). Furthermore, the scores before HSCT were significantly higher in patients who developed SOS than in controls (p = 0.001). The HokUS-6 is an easy and useful way to diagnose and identify the risk of SOS. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in International journal of hematology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12185-021-03137-3 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/86227 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
