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Novel symbionts and potential human pathogens excavated from argasid tick microbiomes that are shaped by dual or single symbiosis

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Title: Novel symbionts and potential human pathogens excavated from argasid tick microbiomes that are shaped by dual or single symbiosis
Authors: Moustafa, Mohamed Abdallah Mohamed Browse this author
Mohamed, Wessam Mohamed Ahmed Browse this author
Lau, Alice C. C. Browse this author
Chatanga, Elisha Browse this author
Qiu, Yongjin Browse this author →KAKEN DB
Hayashi, Naoki Browse this author
Naguib, Doaa Browse this author
Sato, Kozue Browse this author
Takano, Ai Browse this author
Matsuno, Keita Browse this author →KAKEN DB
Nonaka, Nariaki Browse this author →KAKEN DB
Taylor, DeMar Browse this author
Kawabata, Hiroki Browse this author
Nakao, Ryo Browse this author →KAKEN DB
Keywords: Argasid ticks
Dual symbiosis
Vector-borne diseases
Issue Date: 27-Apr-2022
Publisher: Elsevier
Journal Title: Computational and Structural Biotechnology Journal
Volume: 20
Start Page: 1979
End Page: 1992
Publisher DOI: 10.1016/j.csbj.2022.04.020
Abstract: Research on vector-associated microbiomes has been expanding due to increasing emergence of vector borne pathogens and awareness of the importance of symbionts in the vector physiology. However, little is known about microbiomes of argasid (or soft-bodied) ticks due to limited access to specimens. We collected four argasid species (Argas japonicus, Carios vespertilionis, Ornithodoros capensis, and Ornithodoros sawaii) from the nests or burrows of their vertebrate hosts. One laboratory-reared argasid species (Ornithodoros moubata) was also included. Attempts were then made to isolate and characterize potential symbionts/pathogens using arthropod cell lines. Microbial community structure was distinct for each tick species. Coxiella was detected as the predominant symbiont in four tick species where dual symbiosis between Coxiella and Rickettsia or Coxiella and Francisella was observed in C. vespertilionis and O. moubata, respectively. Of note, A. japonicus lacked Coxiella and instead had Occidentia massiliensis and Thiotrichales as alternative symbionts. Our study found strong correlation between tick species and life stage. We successfully isolated Oc. massiliensis and characterized potential pathogens of genera Ehrlichia and Borrelia. The results suggest that there is no consistent trend of microbiomes in relation to tick life stage that fit all tick species and that the final interpretation should be related to the balance between environmental bacterial exposure and endosymbiont ecology. Nevertheless, our findings provide insights on the ecology of tick microbiomes and basis for future investigations on the capacity of argasid ticks to carry novel pathogens with public health importance. (c) 2022 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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