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Hokkaido University Collection of Scholarly and Academic Papers >
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Neural signals regulating motor synchronization in the primate deep cerebellar nuclei
| Title: | Neural signals regulating motor synchronization in the primate deep cerebellar nuclei |
| Authors: | Ken-ichi, Okada Browse this author | | Ryuji, Takeya Browse this author | | Masaki, Tanaka Browse this author →KAKEN DB |
| Issue Date: | 6-May-2022 |
| Publisher: | Nature Portfolio |
| Journal Title: | Nature Communications |
| Volume: | 13 |
| Issue: | 1 |
| Start Page: | 2504 |
| Publisher DOI: | 10.1038/s41467-022-30246-2 |
| Abstract: | It remains unclear how the brain represents information regarding synchronized movements. Here, the authors investigated the response properties of cerebellar cells in macaques performing a synchronized saccade task and found three groups of cerebellar neurons with distinct peri-saccade response profiles. Movements synchronized with external rhythms are ubiquitous in our daily lives. Despite the involvement of the cerebellum, the underlying mechanism remains unclear. In monkeys performing synchronized saccades to periodically alternating visual stimuli, we found that neuronal activity in the cerebellar dentate nucleus correlated with the timing of the next saccade and the current temporal error. One-third of the neurons were active regardless of saccade direction and showed greater activity for synchronized than for reactive saccades. During the transition from reactive to predictive saccades in each trial, the activity of these neurons coincided with target onset, representing an internal model of rhythmic structure rather than a specific motor command. The behavioural changes induced by electrical stimulation were explained by activating different groups of neurons at various strengths, suggesting that the lateral cerebellum contains multiple functional modules for the acquisition of internal rhythms, predictive motor control, and error detection during synchronized movements. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86281 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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