| Title: | Visual echocardiographic scoring system of the left ventricular filling pressure and outcomes of heart failure with preserved ejection fraction |
| Authors: | Murayama, Michito Browse this author |
| Iwano, Hiroyuki Browse this author →KAKEN DB |
| Obokata, Masaru Browse this author |
| Harada, Tomonari Browse this author |
| Omote, Kazunori Browse this author |
| Kagami, Kazuki Browse this author |
| Tsujinaga, Shingo Browse this author |
| Chiba, Yasuyuki Browse this author |
| Ishizaka, Suguru Browse this author |
| Motoi, Ko Browse this author |
| Tamaki, Yoji Browse this author |
| Aoyagi, Hiroyuki Browse this author |
| Nakabachi, Masahiro Browse this author |
| Nishino, Hisao Browse this author |
| Yokoyama, Shinobu Browse this author |
| Tanemura, Asuka Browse this author |
| Okada, Kazunori Browse this author |
| Kaga, Sanae Browse this author |
| Nishida, Mutsumi Browse this author |
| Nagai, Toshiyuki Browse this author |
| Kurabayashi, Masahiko Browse this author |
| Anzai, Toshihisa Browse this author →KAKEN DB |
| Keywords: | echocardiography |
| heart failure with preserved ejection fraction |
| left ventricular filling pressure |
| VMT score |
| outcome |
| prognosis |
| Issue Date: | May-2022 |
| Publisher: | Oxford University Press |
| Journal Title: | European heart journal cardiovascular Imaging |
| Volume: | 23 |
| Issue: | 5 |
| Start Page: | 616 |
| End Page: | 626 |
| Publisher DOI: | 10.1093/ehjci/jeab208 |
| Abstract: | Aims Elevated left ventricular filling pressure (LVFP) is a powerful indicator of worsening clinical outcomes in heart failure with preserved ejection fraction (HFpEF); however, detection of elevated LVFP is often challenging. This study aimed to determine the association between the newly proposed echocardiographic LVFP parameter, visually assessed time difference between the mitral valve and tricuspid valve opening (VMT) score, and clinical outcomes of HFpEF. Methods and results We retrospectively investigated 310 well-differentiated HFpEF patients in stable conditions. VMT was scored from 0 to 3 using two-dimensional echocardiographic images, and VMT >= 2 was regarded as a sign of elevated LVFP. The primary endpoint was a composite of cardiac death or heart failure hospitalization during the 2 years after the echocardiographic examination. In all patients, Kaplan-Meier curves showed that VMT >= 2 (n = 54) was associated with worse outcomes than the VMT <= 1 group (n = 256) (P < 0.001). Furthermore, VMT >= 2 was associated with worse outcomes when tested in 100 HFpEF patients with atrial fibrillation (AF) (P = 0.026). In the adjusted model, VMT >= 2 was independently associated with the primary outcome (hazard ratio 2.60, 95% confidence interval 1.46-4.61; P = 0.001). Additionally, VMT scoring provided an incremental prognostic value over clinically relevant variables and diastolic function grading (chi(2) 10.8-16.3, P = 0.035). Conclusions In patients with HFpEF, the VMT score was independently and incrementally associated with adverse clinical outcomes. Moreover, it could also predict clinical outcomes in HFpEF patients with AF. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86282 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
