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Changes in Serum Levels of Ketone Bodies and Human Chorionic Gonadotropin during Pregnancy in Relation to the Neonatal Body Shape : A Retrospective Analysis
| Title: | Changes in Serum Levels of Ketone Bodies and Human Chorionic Gonadotropin during Pregnancy in Relation to the Neonatal Body Shape : A Retrospective Analysis |
| Authors: | Noshiro, Kiwamu Browse this author | | Umazume, Takeshi Browse this author →KAKEN DB | | Hattori, Rifumi Browse this author | | Kataoka, Soromon Browse this author | | Yamada, Takashi Browse this author | | Watari, Hidemichi Browse this author →KAKEN DB |
| Keywords: | ketone body | | pregnancy | | morning sickness | | hyperemesis gravidarum | | human chorionic gonadotropin (HCG) |
| Issue Date: | May-2022 |
| Publisher: | MDPI |
| Journal Title: | Nutrients |
| Volume: | 14 |
| Issue: | 9 |
| Start Page: | 1971 |
| Publisher DOI: | 10.3390/nu14091971 |
| Abstract: | Among the physiological changes occurring during pregnancy, the benefits of morning sickness, which is likely mediated by human chorionic gonadotropin (HCG) and induces serum ketone production, are unclear. We investigated the relationship between serum levels of ketone bodies and HCG in the first, second, and third trimesters and neonatal body shape (i.e., birth weight, length, head circumference, and chest circumference) in 245 pregnant women. Serum levels of 3-hydroxybutyric acid peaked in late-stage compared with early stage pregnancy (27.8 [5.0-821] vs. 42.2 [5.0-1420] mu mol/L, median [range], p < 0.001). However, serum levels of ketone bodies and HCG did not correlate with neonatal body shape. When weight loss during pregnancy was used as an index of morning sickness, a higher pre-pregnancy body mass index was associated with greater weight loss. This study is the first to show that serum ketone body levels are maximal in the third trimester of pregnancy. As the elevation of serum ketone bodies in the third trimester is a physiological change, high serum levels of ketone bodies may be beneficial for mothers and children. One of the possible biological benefits of morning sickness is the prevention of diseases that have an increased incidence due to weight gain during pregnancy. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86287 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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