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Optical biopsy for esophageal squamous cell neoplasia by using endocytoscopy

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Title: Optical biopsy for esophageal squamous cell neoplasia by using endocytoscopy
Authors: Shimoda, Yoshihiko Browse this author
Shimizu, Yuichi Browse this author
Takahashi, Hiroaki Browse this author
Okahara, Satoshi Browse this author
Miyake, Takakazu Browse this author
Ichihara, Shin Browse this author
Tanaka, Ikko Browse this author
Inoue, Masaki Browse this author
Kinowaki, Sayoko Browse this author
Ono, Masayoshi Browse this author
Yamamoto, Keiko Browse this author
Ono, Shoko Browse this author
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: Diagnostic accuracy
Esophageal cancer
Intraepithelial neoplasia
Optical biopsy
Issue Date: 2022
Publisher: BioMed Central
Journal Title: BMC gastroenterology
Volume: 22
Issue: 1
Start Page: 259
Publisher DOI: 10.1186/s12876-022-02335-5
Abstract: Background Endocytoscopy (ECS) enables microscopic observation in vivo for the gastrointestinal mucosa; however, there has been no prospective study in which the diagnostic accuracy of ECS for lesions that have not yet undergone histological diagnosis was evaluated. We conducted a surveillance study for patients in a high-risk group of esophageal squamous cell carcinoma (ESCC) and evaluated the in vivo histological diagnostic accuracy of ECS. Methods This study was a multicenter prospective study. We enrolled 197 patients in the study between September 1, 2019 and November 30, 2020. The patients first underwent white light imaging and narrow band imaging, and ultra-high magnifying observation was performed if there was a lesion suspected to be an esophageal tumor. Endoscopic submucosal dissection (ESD) was later performed for lesions that were diagnosed to be ESCC by ECS without biopsy. We evaluated the diagnostic accuracy of ECS for esophageal tumorous lesions. Results ESD was performed for 37 patients (41 lesions) who were diagnosed as having ESCC by ECS, and all of them were histopathologically diagnosed as having ESCC. The sensitivity [95% confidence interval (CI)] was 97.6% (87.7-99.7%), specificity (95% CI) was 100% (92.7-100%), diagnostic accuracy (95% CI) was 98.9% (94.0-99.8%), positive predictive value (PPV) (95% CI) was 100% (91.4-100%) and negative predictive value (NPV) (95% CI) was 98.0% (89.5-99.7%). Conclusions ECS has a high diagnostic accuracy and there were no false positives in cases diagnosed and resected as ESCC. Optical biopsy by using ECS for esophageal lesions that are suspected to be tumorous is considered to be sufficient in clinical practice.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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