| Title: | Optical biopsy for esophageal squamous cell neoplasia by using endocytoscopy |
| Authors: | Shimoda, Yoshihiko Browse this author |
| Shimizu, Yuichi Browse this author |
| Takahashi, Hiroaki Browse this author |
| Okahara, Satoshi Browse this author |
| Miyake, Takakazu Browse this author |
| Ichihara, Shin Browse this author |
| Tanaka, Ikko Browse this author |
| Inoue, Masaki Browse this author |
| Kinowaki, Sayoko Browse this author |
| Ono, Masayoshi Browse this author |
| Yamamoto, Keiko Browse this author |
| Ono, Shoko Browse this author |
| Sakamoto, Naoya Browse this author →KAKEN DB |
| Keywords: | Diagnostic accuracy |
| Endocytoscopy |
| Esophageal cancer |
| Intraepithelial neoplasia |
| Optical biopsy |
| Issue Date: | 2022 |
| Publisher: | BioMed Central |
| Journal Title: | BMC gastroenterology |
| Volume: | 22 |
| Issue: | 1 |
| Start Page: | 259 |
| Publisher DOI: | 10.1186/s12876-022-02335-5 |
| Abstract: | Background Endocytoscopy (ECS) enables microscopic observation in vivo for the gastrointestinal mucosa; however, there has been no prospective study in which the diagnostic accuracy of ECS for lesions that have not yet undergone histological diagnosis was evaluated. We conducted a surveillance study for patients in a high-risk group of esophageal squamous cell carcinoma (ESCC) and evaluated the in vivo histological diagnostic accuracy of ECS. Methods This study was a multicenter prospective study. We enrolled 197 patients in the study between September 1, 2019 and November 30, 2020. The patients first underwent white light imaging and narrow band imaging, and ultra-high magnifying observation was performed if there was a lesion suspected to be an esophageal tumor. Endoscopic submucosal dissection (ESD) was later performed for lesions that were diagnosed to be ESCC by ECS without biopsy. We evaluated the diagnostic accuracy of ECS for esophageal tumorous lesions. Results ESD was performed for 37 patients (41 lesions) who were diagnosed as having ESCC by ECS, and all of them were histopathologically diagnosed as having ESCC. The sensitivity [95% confidence interval (CI)] was 97.6% (87.7-99.7%), specificity (95% CI) was 100% (92.7-100%), diagnostic accuracy (95% CI) was 98.9% (94.0-99.8%), positive predictive value (PPV) (95% CI) was 100% (91.4-100%) and negative predictive value (NPV) (95% CI) was 98.0% (89.5-99.7%). Conclusions ECS has a high diagnostic accuracy and there were no false positives in cases diagnosed and resected as ESCC. Optical biopsy by using ECS for esophageal lesions that are suspected to be tumorous is considered to be sufficient in clinical practice. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86296 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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