| Title: | The utility of diffusion-weighted T2 mapping for the prediction of histological tumor grade in patients with head and neck squamous cell carcinoma |
| Authors: | Fujima, Noriyuki Browse this author →KAKEN DB |
| Shimizu, Yukie Browse this author |
| Yoneyama, Masami Browse this author |
| Nakagawa, Junichi Browse this author |
| Kameda, Hiroyuki Browse this author |
| Harada, Taisuke Browse this author |
| Hamada, Seijiro Browse this author |
| Suzuki, Takayoshi Browse this author |
| Tsushima, Nayuta Browse this author |
| Kano, Satoshi Browse this author |
| Homma, Akihiro Browse this author |
| Kudo, Kohsuke Browse this author →KAKEN DB |
| Keywords: | Diffusion |
| T2 mapping |
| head and neck squamous cell carcinoma (SCC) |
| histological grade |
| Issue Date: | 15-Jul-2022 |
| Publisher: | AME Publishing Company |
| Journal Title: | Quantitative imaging in medicine and surgery |
| Volume: | 12 |
| Issue: | 8 |
| Start Page: | 4024 |
| End Page: | 4032 |
| Publisher DOI: | 10.21037/qims-22-136 |
| Abstract: | Background: In head and neck cancers, histopathological information is important for the determination of the tumor characteristics and for predicting the prognosis. The aim of this study was to assess the utility of diffusion-weighted T2 (DW-T2) mapping for the evaluation of tumor hisinlogical grade in patients with head and neck squamous cell carcinoma (SCC). Methods: The cases of 41 patients with head and neck SCC (21 well/moderately and 17 poorly differentiated SCC) were retrospectively analyzed. All patients received MR scanning using a 3-Tesla MR unit. The conventional T2 value, DW-T2 value, ratio of DW-T2 value to conventional T2 value, and apparent diffusion coefficient (ADC) were calculated using signal information from the DW-T2 mapping sequence with a manually placed region of interest (ROI). Results: ADC values in the poorly differentiated SCC group were significantly lower than those in the moderately/well differentiated SCC group (P<0.05). The ratio of Dvv-T2 value to conventional T2 value was also significantly different between poorly and moderately/well differentiated SCC groups (P<0.01). Receiver operating characteristic (ROC) curve analysis of ADC values showed a sensitivity of 0.76, specificity of 0.67, positive predictive value (PPV) of 0.62, negative predictive value (NPV) of 0.8, accuracy of 0.71 and area under the curve (AUC) of 0.73, whereas the ROC curve analysis of the ratio of DW-T2 value to conventional T2 value showed a sensitivity of 0.76, specificity of 0.83, PPV of 0.76, NPV of 0.83, accuracy of 0.8 and AUC of 0.82. Conclusions: DW-T2 mapping might be useful as supportive information for the determination of tumor histological grade in patients with head and neck SCC. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86304 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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