| Title: | Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis |
| Authors: | Wada, Takeshi Browse this author →KAKEN DB |
| Yamakawa, Kazuma Browse this author |
| Kabata, Daijiro Browse this author |
| Abe, Toshikazu Browse this author |
| Ogura, Hiroshi Browse this author |
| Shiraishi, Atsushi Browse this author |
| Saitoh, Daizoh Browse this author |
| Kushimoto, Shigeki Browse this author |
| Fujishima, Seitaro Browse this author |
| Mayumi, Toshihiko Browse this author |
| Hifumi, Toru Browse this author |
| Shiino, Yasukazu Browse this author |
| Nakada, Taka-aki Browse this author |
| Tarui, Takehiko Browse this author |
| Otomo, Yasuhiro Browse this author |
| Okamoto, Kohji Browse this author |
| Umemura, Yutaka Browse this author |
| Kotani, Joji Browse this author |
| Sakamoto, Yuichiro Browse this author |
| Sasaki, Junichi Browse this author |
| Shiraishi, Shin-ichiro Browse this author |
| Takuma, Kiyotsugu Browse this author |
| Tsuruta, Ryosuke Browse this author |
| Hagiwara, Akiyoshi Browse this author |
| Masuno, Tomohiko Browse this author |
| Takeyama, Naoshi Browse this author |
| Yamashita, Norio Browse this author |
| Ikeda, Hiroto Browse this author |
| Ueyama, Masashi Browse this author |
| Fujimi, Satoshi Browse this author |
| Gando, Satoshi Browse this author →KAKEN DB |
| Issue Date: | 3-Jun-2022 |
| Publisher: | Nature Portfolio |
| Journal Title: | Scientific reports |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 9304 |
| Publisher DOI: | 10.1038/s41598-022-13346-3 |
| Abstract: | Disseminated intravascular coagulation (DIC) is one of the major organ dysfunctions associated with sepsis. This retrospective secondary analysis comprised data from a prospective multicenter study to investigate the age-related differences in the survival benefit of anticoagulant therapy in sepsis according to the DIC diagnostic criteria. Adult patients with severe sepsis based on the Sepsis-2 criteria were enrolled and divided into the following groups: (1) anticoagulant group (patients who received anticoagulant therapy) and (2) non-anticoagulant group (patients who did not receive anticoagulant therapy). Patients in the former group were administered antithrombin, recombinant human thrombomodulin, or their combination. The increases in the risk of hospital mortality were suppressed in the high-DIC-score patients aged 60-70 years receiving anticoagulant therapy. No favorable association of anti-coagulant therapy with hospital mortality was observed in patients aged 50 years and 80 years. Furthermore, anticoagulant therapy in the lower-DIC-score range increased the risk of hospital mortality in patients aged 50-60 years. In conclusion, anticoagulant therapy was associated with decreased hospital mortality according to a higher DIC score in septic patients aged 60-70 years. Anticoagulant therapy, however, was not associated with a better outcome in relatively younger and older patients with sepsis. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86305 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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