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Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis

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Title: Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis
Authors: Wada, Takeshi Browse this author →KAKEN DB
Yamakawa, Kazuma Browse this author
Kabata, Daijiro Browse this author
Abe, Toshikazu Browse this author
Ogura, Hiroshi Browse this author
Shiraishi, Atsushi Browse this author
Saitoh, Daizoh Browse this author
Kushimoto, Shigeki Browse this author
Fujishima, Seitaro Browse this author
Mayumi, Toshihiko Browse this author
Hifumi, Toru Browse this author
Shiino, Yasukazu Browse this author
Nakada, Taka-aki Browse this author
Tarui, Takehiko Browse this author
Otomo, Yasuhiro Browse this author
Okamoto, Kohji Browse this author
Umemura, Yutaka Browse this author
Kotani, Joji Browse this author
Sakamoto, Yuichiro Browse this author
Sasaki, Junichi Browse this author
Shiraishi, Shin-ichiro Browse this author
Takuma, Kiyotsugu Browse this author
Tsuruta, Ryosuke Browse this author
Hagiwara, Akiyoshi Browse this author
Masuno, Tomohiko Browse this author
Takeyama, Naoshi Browse this author
Yamashita, Norio Browse this author
Ikeda, Hiroto Browse this author
Ueyama, Masashi Browse this author
Fujimi, Satoshi Browse this author
Gando, Satoshi Browse this author →KAKEN DB
Issue Date: 3-Jun-2022
Publisher: Nature Portfolio
Journal Title: Scientific reports
Volume: 12
Issue: 1
Start Page: 9304
Publisher DOI: 10.1038/s41598-022-13346-3
Abstract: Disseminated intravascular coagulation (DIC) is one of the major organ dysfunctions associated with sepsis. This retrospective secondary analysis comprised data from a prospective multicenter study to investigate the age-related differences in the survival benefit of anticoagulant therapy in sepsis according to the DIC diagnostic criteria. Adult patients with severe sepsis based on the Sepsis-2 criteria were enrolled and divided into the following groups: (1) anticoagulant group (patients who received anticoagulant therapy) and (2) non-anticoagulant group (patients who did not receive anticoagulant therapy). Patients in the former group were administered antithrombin, recombinant human thrombomodulin, or their combination. The increases in the risk of hospital mortality were suppressed in the high-DIC-score patients aged 60-70 years receiving anticoagulant therapy. No favorable association of anti-coagulant therapy with hospital mortality was observed in patients aged 50 years and 80 years. Furthermore, anticoagulant therapy in the lower-DIC-score range increased the risk of hospital mortality in patients aged 50-60 years. In conclusion, anticoagulant therapy was associated with decreased hospital mortality according to a higher DIC score in septic patients aged 60-70 years. Anticoagulant therapy, however, was not associated with a better outcome in relatively younger and older patients with sepsis.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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