| Title: | Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma |
| Authors: | Noji, Takehiro Browse this author →KAKEN DB |
| Uemura, Satoko Browse this author |
| Wiggers, Jimme K. Browse this author |
| Tanaka, Kimitaka Browse this author |
| Nakanishi, Yoshitsugu Browse this author |
| Asano, Toshimichi Browse this author |
| Nakamura, Toru Browse this author |
| Tsuchikawa, Takahiro Browse this author |
| Okamura, Keisuke Browse this author |
| Olthof, Pim B. Browse this author |
| Jarnagin, William R. Browse this author |
| van Gulik, Thomas M. Browse this author |
| Hirano, Satoshi Browse this author →KAKEN DB |
| Keywords: | Perihilar cholangiocarcinoma (PHCC) |
| post operative mortality score |
| post-hepatectomy liver failure score (PHLFS) |
| validation study |
| Issue Date: | Jun-2022 |
| Publisher: | AME Publishing Company |
| Journal Title: | Hepatobiliary Surgery and Nutrition |
| Volume: | 11 |
| Issue: | 3 |
| Start Page: | 375 |
| End Page: | 385 |
| Publisher DOI: | 10.21037/hbsn-20-660 |
| Abstract: | Background: Surgery for perihilar cholangiocarcinoma (PHCC) remains a challenging procedure with high morbidity and mortality. The Academic Medical Center (Amsterdam UMC) and Memorial Sloan Kettering Cancer Center proposed a postoperative mortality risk score (POMRS) and post-hepatectomy liver failure score (PHLFS) to predict patient outcomes. This study aimed to validate the POMRS and PHLFS for PHCC patients at Hokkaido University. Methods: Medical records of 260 consecutive PHCC patients who had undergone major hepatectomy with extrahepatic bile duct resection without pancreaticoduodenectomy at Hokkaido University between March 2001 and November 2018 were evaluated to validate the PHLFS and POMRS. Results: The observed risks for PHLF were 13.7%, 24.5%, and 39.8% for the low-risk, intermediate risk, and high-risk groups, respectively, in the study cohort. A receiver-operator characteristic (ROC) analysis revealed that the PHLFS had moderate predictive value, with an analysis under the curve (AUC) value of 0.62. Mortality rates based on the POMRS were 1.7%, 5%, and 5.1% for the low-risk, intermediate-risk, and high-risk groups, respectively. The ROC analysis demonstrated an AUC value of 0.58. Conclusions: This external validation study showed that for PHLFS the threshold for discrimination in an Eastern cohort was reached (AUC >0.6), but it would require optimization of the model before use in clinical practice is acceptable. The POMRS were not applicable in the eastern cohort. Further external validation is recommended. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86308 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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