HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Institute for Genetic Medicine >
Peer-reviewed Journal Articles, etc >

IFN-alpha/beta-mediated NK2R expression is related to the malignancy of colon cancer cells

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: IFN-alpha/beta-mediated NK2R expression is related to the malignancy of colon cancer cells
Authors: Xiang, Huihui Browse this author
Toyoshima, Yujiro Browse this author
Shen, Weidong Browse this author
Wang, Xiangdong Browse this author
Okada, Naoki Browse this author
Kii, Shuhei Browse this author
Sugiyama, Ko Browse this author
Nagato, Toshihiro Browse this author
Kobayashi, Hiroya Browse this author
Ikeo, Kazuho Browse this author
Hashimoto, Shinichi Browse this author
Tanino, Mishie Browse this author
Taketomi, Akinobu Browse this author
Kitamura, Hidemitsu Browse this author →KAKEN DB
Keywords: colon cancer
neurokinin-2 receptor
type I IFN
Issue Date: 15-Jul-2022
Publisher: John Wiley & Sons
Journal Title: Cancer science
Publisher DOI: 10.1111/cas.15397
Abstract: Neurokinin 2 receptor (NK2R), a G protein-coupled receptor for neurokinin A (NKA), a tachykinin family member, regulates various physiological functions including pain response, relaxation of smooth muscle, dilation of blood vessels, and vascular permeability. However, the precise role and regulation of NK2R expression in cancer cells have not been fully elucidated. In this study, we found that high NK2R gene expression was correlated with the poor survival of colorectal cancer patients, and Interferon (IFN-alpha/beta) stimulation significantly enhanced NK2R gene expression level of colon cancer cells in a Janus kinas 1/2 (JAK 1/2)-dependent manner. NKA stimulation augmented viability/proliferation and phosphorylation of Extracellular-signal-regulated kinase 1/2 (ERK1/2) levels of IFN-alpha/beta-treated colon cancer cells and NK2R blockade by using a selective antagonist reduced the proliferation in vitro. Administration of an NK2R antagonist alone or combined with polyinosinic-polycytidylic acid, a synthetic analog of double-stranded RNA, to CT26-bearing mice significantly suppressed tumorigenesis. NK2R-overexpressing CT26 cells showed enhanced tumorigenesis and metastatic colonization in both lung and liver after the inoculation into mice. These findings indicate that IFN-alpha/beta-mediated NK2R expression is related to the malignancy of colon cancer cells, suggesting that NK2R blockade may be a promising strategy for colon cancers.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University