| Title: | High CRP-albumin ratio predicts poor prognosis in transplant ineligible elderly patients with newly diagnosed acute myeloid leukemia |
| Authors: | Senjo, Hajime Browse this author |
| Onozawa, Masahiro Browse this author |
| Hidaka, Daisuke Browse this author |
| Yokoyama, Shota Browse this author |
| Yamamoto, Satoshi Browse this author |
| Tsutsumi, Yutaka Browse this author |
| Haseyama, Yoshihito Browse this author |
| Nagashima, Takahiro Browse this author |
| Mori, Akio Browse this author |
| Ota, Shuichi Browse this author |
| Sakai, Hajime Browse this author |
| Ishihara, Toshimichi Browse this author |
| Miyagishima, Takuto Browse this author |
| Kakinoki, Yasutaka Browse this author |
| Kurosawa, Mitsutoshi Browse this author |
| Kobayashi, Hajime Browse this author |
| Iwasaki, Hiroshi Browse this author |
| Hashimoto, Daigo Browse this author |
| Kondo, Takeshi Browse this author |
| Teshima, Takanori Browse this author →KAKEN DB |
| Issue Date: | 2022 |
| Publisher: | Nature Portfolio |
| Journal Title: | Scientific reports |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 8885 |
| Publisher DOI: | 10.1038/s41598-022-12813-1 |
| Abstract: | Acute myeloid leukemia (AML) patients older than 65 years have a poor prognosis. Recently, CAR (C-reactive-protein/albumin ratio) has been actively reported as a prognostic index reflecting the nutritional and inflammatory status of elderly patients with solid tumors, but the usefulness of this index as a prognostic indicator in transplant-ineligible elderly AML patients has not been investigated. We studied genetic alterations and CARs in 188 newly diagnosed AML patients aged 65 years or older who were treated in a multicenter setting and had treated without HSCT. Both NCCN 2017 risk group, reflecting the genetic component of the tumor, and CAR, reflecting the inflammatory and nutritional status of the patient, successfully stratified the overall survival (OS) of the patients (2-year OS; CAR low vs high, 42.3% vs 17.8%, P < 0.001). Furthermore, in multivariate analysis, NCCN 2017 poor group and high CAR were extracted as independent poor prognostic factors predicting 2-year OS in the current study. We found, for the first time, that CAR at diagnosis predicted the prognosis of elderly patients with newly diagnosed AML treated without HSCT. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86310 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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