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High CRP-albumin ratio predicts poor prognosis in transplant ineligible elderly patients with newly diagnosed acute myeloid leukemia

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Title: High CRP-albumin ratio predicts poor prognosis in transplant ineligible elderly patients with newly diagnosed acute myeloid leukemia
Authors: Senjo, Hajime Browse this author
Onozawa, Masahiro Browse this author
Hidaka, Daisuke Browse this author
Yokoyama, Shota Browse this author
Yamamoto, Satoshi Browse this author
Tsutsumi, Yutaka Browse this author
Haseyama, Yoshihito Browse this author
Nagashima, Takahiro Browse this author
Mori, Akio Browse this author
Ota, Shuichi Browse this author
Sakai, Hajime Browse this author
Ishihara, Toshimichi Browse this author
Miyagishima, Takuto Browse this author
Kakinoki, Yasutaka Browse this author
Kurosawa, Mitsutoshi Browse this author
Kobayashi, Hajime Browse this author
Iwasaki, Hiroshi Browse this author
Hashimoto, Daigo Browse this author
Kondo, Takeshi Browse this author
Teshima, Takanori Browse this author →KAKEN DB
Issue Date: 2022
Publisher: Nature Portfolio
Journal Title: Scientific reports
Volume: 12
Issue: 1
Start Page: 8885
Publisher DOI: 10.1038/s41598-022-12813-1
Abstract: Acute myeloid leukemia (AML) patients older than 65 years have a poor prognosis. Recently, CAR (C-reactive-protein/albumin ratio) has been actively reported as a prognostic index reflecting the nutritional and inflammatory status of elderly patients with solid tumors, but the usefulness of this index as a prognostic indicator in transplant-ineligible elderly AML patients has not been investigated. We studied genetic alterations and CARs in 188 newly diagnosed AML patients aged 65 years or older who were treated in a multicenter setting and had treated without HSCT. Both NCCN 2017 risk group, reflecting the genetic component of the tumor, and CAR, reflecting the inflammatory and nutritional status of the patient, successfully stratified the overall survival (OS) of the patients (2-year OS; CAR low vs high, 42.3% vs 17.8%, P < 0.001). Furthermore, in multivariate analysis, NCCN 2017 poor group and high CAR were extracted as independent poor prognostic factors predicting 2-year OS in the current study. We found, for the first time, that CAR at diagnosis predicted the prognosis of elderly patients with newly diagnosed AML treated without HSCT.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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