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Hokkaido University Collection of Scholarly and Academic Papers >
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The incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in Japanese hospitals : A large-scale clinical study
| Title: | The incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in Japanese hospitals : A large-scale clinical study |
| Authors: | Ichikawa, Nobuki Browse this author →KAKEN DB | | Homma, Shigenori Browse this author →KAKEN DB | | Funakoshi, Tohru Browse this author | | Obuchi, Keisuke Browse this author | | Ohshima, Takahiro Browse this author | | Uemura, Kazuhito Browse this author | | Kon, Hirofumi Browse this author | | Ohno, Yosuke Browse this author | | Yokota, Ryoichi Browse this author | | Taketomi, Akinobu Browse this author →KAKEN DB |
| Keywords: | colorectal neoplasms | | ischemic heart disease | | laparoscopy | | stroke | | thrombosis |
| Issue Date: | May-2022 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Annals of gastroenterological surgery |
| Volume: | 6 |
| Issue: | 3 |
| Start Page: | 396 |
| End Page: | 404 |
| Publisher DOI: | 10.1002/ags3.12531 |
| Abstract: | Aim The aim of this retrospective study was to investigate the incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer. Methods This study involved 2017 patients with stages 0-III colorectal cancer who underwent laparoscopic surgery at 17 Japanese hospitals between January 2010 and December 2013. We assessed the incidence of postoperative cardiovascular thrombotic and haemorrhagic complications. Results Laparoscopic surgeries were performed in 1152 men and 865 women with 1405 colon and 612 rectal cancers, respectively. Overall, 3%, 38%, 17%, 8%, and 9% of patients had comorbidities of heart failure, high blood pressure, diabetes, history of stroke, and vascular disease, respectively. Antithrombotic agents were being consumed by 17% of patients. The types (and perioperative rest periods) of the antithrombotic agents were aspirin in 58% (18.6 days), clopidogrel in 19% (21.1 days), cilostazol in 13% (13.3 days), and warfarin potassium in 21% (14.6 days) of cases with antithrombotic agents. Surgical time and blood loss in the total cohort were 234 minutes and 56 mL. Four cases (0.2%) had cardiovascular thrombotic complications, including one severe cardiac infarction and one stroke with major sequelae (CHADS2 scores were 2 points in both cases). Hemorrhagic complications occurred in 19 cases (0.9%). In particular, the incidence of the major gastroduodenal haemorrhagic ulcer was higher in cases with antithrombotic agents than without them (0.05% vs 0%, P = .02). Conclusion The incidence of cardiovascular thrombotic complications was rare, although severe cardiac infarction and stroke could occur even after minimally invasive surgery in colorectal cancer. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86371 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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