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Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals

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Title: Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals
Authors: Itoigawa, Akihiro Browse this author
Hayakawa, Takashi Browse this author →KAKEN DB
Zhou, Yang Browse this author
Manning, Adrian D. Browse this author
Zhang, Guojie Browse this author
Grutzner, Frank Browse this author
Imai, Hiroo Browse this author →KAKEN DB
Keywords: TAS2R
molecular evolution
Issue Date: Jun-2022
Publisher: Oxford University Press
Journal Title: Molecular Biology and Evolution
Volume: 39
Issue: 6
Start Page: msac107
Publisher DOI: 10.1093/molbev/msac107
Abstract: Egg-laying mammals (monotremes) are a sister Glade of therians (placental mammals and marsupials) and a key Glade to understand mammalian evolution. They are classified into platypus and echidna, which exhibit distinct ecological features such as habitats and diet. Chemosensory genes, which encode sensory receptors for taste and smell, are believed to adapt to the individual habitats and diet of each mammal. In this study, we focused on the molecular evolution of bitter taste receptors (TAS2Rs) in monotremes. The sense of bitter taste is important to detect potentially harmful substances. We comprehensively surveyed agonists of all TAS2Rs in platypus (Ornithorhynchus anatinus) and short-beaked echidna (Tachyglossus aculeatus) and compared their functions with orthologous TAS2Rs of marsupial and placental mammals (i.e., therians). As results, the agonist screening revealed that the deorphanized monotreme receptors were functionally diversified. Platypus TAS2Rs had broader receptive ranges of agonists than those of echidna TAS2Rs. While platypus consumes a variety of aquatic invertebrates, echidna mainly consumes subterranean social insects (ants and termites) as well as other invertebrates. This result indicates that receptive ranges of TAS2Rs could be associated with feeding habits in monotremes. Furthermore, some orthologous receptors in monotremes and therians responded to beta-glucosides, which are feeding deterrents in plants and insects. These results suggest that the ability to detect beta-glucosides and other substances might be shared and ancestral among mammals.
Type: article
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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