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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Proteinous pancreatic lipase inhibitor is responsible for the antiobesity effect of young barley (Hordeum vulgare L.) leaf extract
| Title: | Proteinous pancreatic lipase inhibitor is responsible for the antiobesity effect of young barley (Hordeum vulgare L.) leaf extract |
| Authors: | Kato, Eisuke Browse this author →KAKEN DB | | Tsuruma, Ai Browse this author | | Amishima, Ayaka Browse this author | | Satoh, Hiroshi Browse this author |
| Keywords: | barley | | Hordeum vulgare | | obesity | | proteinous lipase inhibitor |
| Issue Date: | Aug-2021 |
| Publisher: | Oxford University Press |
| Journal Title: | Bioscience biotechnology and biochemistry |
| Volume: | 85 |
| Issue: | 8 |
| Start Page: | 1885 |
| End Page: | 1889 |
| Publisher DOI: | 10.1093/bbb/zbab096 |
| Abstract: | Young barley leaves (Hordeum vulgare L.) have various health effects and are employed as an ingredient in the production of health-promoting foods. Promoting antiobesity is one such health effect; however, the mechanism and bioactive compounds are unclear. In this research, young barley leaf extract (YB) was demonstrated to possess pancreatic lipase inhibitory activity. The addition of YB to a high-fat diet in mice increased fecal lipid content, indicating reduced absorption of lipids as the mechanism underlying antiobesity effect. The investigation of bioactive compounds in YB resulted in the identification of fructose-bisphosphate aldolase as a proteinous lipase inhibitor. Maximum inhibition of the protein was 45%, but inhibition was displayed at a concentration as low as 16 ng/mL, which is a characteristic inhibition compared with other reported proteinous lipase inhibitors. [GRAPHICS] . |
| Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in Japan Society for Bioscience, Biotechnology, and Agrochemistry following peer review. The version of record Eisuke Kato, Ai Tsuruma, Ayaka Amishima, Hiroshi Satoh, Proteinous pancreatic lipase inhibitor is responsible for the antiobesity effect of young barley (Hordeum vulgare L.) leaf extract, Bioscience, Biotechnology, and Biochemistry, Volume 85, Issue 8, August 2021, Pages 1885-1889 is available online at: https://doi.org/10.1093/bbb/zbab096. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/86420 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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