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Combined assessment of pulmonary arterial enlargement and coronary calcification predicts the prognosis of patients with chronic obstructive pulmonary disease

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Title: Combined assessment of pulmonary arterial enlargement and coronary calcification predicts the prognosis of patients with chronic obstructive pulmonary disease
Authors: Takei, Nozomu Browse this author
Suzuki, Masaru Browse this author →KAKEN DB
Tanabe, Naoya Browse this author
Oguma, Akira Browse this author
Shimizu, Kaoruko Browse this author
Kimura, Hirokazu Browse this author
Makita, Hironi Browse this author
Sato, Susumu Browse this author
Hirai, Toyohiro Browse this author
Yokota, Isao Browse this author
Konno, Satoshi Browse this author →KAKEN DB
Nishimura, Masaharu Browse this author →KAKEN DB
Keywords: Chronic obstructive pulmonary disease
Pulmonary hypertension
Cardiovascular disease
Computed tomography
Issue Date: Aug-2021
Publisher: Elsevier
Journal Title: Respiratory medicine
Volume: 185
Start Page: 106520
Publisher DOI: 10.1016/j.rmed.2021.106520
Abstract: Introduction: In chronic obstructive pulmonary disease (COPD), chest computed tomography (CT) provides clinically important cardiovascular findings, which include diameter of pulmonary artery (PA), its ratio to the diameter of the aorta (PA:A ratio), and coronary artery calcium score (CACS). The clinical importance of these cardiovascular findings has not been fully assessed in Japan, where cardiovascular morbidity and/or mortality is reported to be much less compared with Western counterparts. Methods: PA diameter and PA:A ratio were measured in 172 and 130 patients with COPD who enrolled in the Hokkaido COPD cohort study and the Kyoto University cohort, respectively. CACS was measured in 131 and 128 patients in each cohort. Results: While the highest quartile group in PA diameter was associated with higher all-cause mortality compared to the lowest quartile group in both cohorts, individual assessments of PA:A ratio and CACS were not associated with the long-term clinical outcomes. When PA diameter and CACS were combined, patients with PA enlargement (diameter >29.5 mm) and/or coronary calcification (score >440.8) were associated with higher all-cause mortality in both cohorts. Conclusion: Combined assessment of PA enlargement and CACS was associated with poor prognosis, which provides a clinical advantage in management of patients with COPD even in geographical regions with lower risk of cardiovascular diseases.
Rights: © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鈴木 雅

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