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Hokkaido University Collection of Scholarly and Academic Papers >
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Behavioral characteristics of 5-HT2C receptor knockout mice : Locomotor activity, anxiety-, and fear memory-related behaviors
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| Title: | Behavioral characteristics of 5-HT2C receptor knockout mice : Locomotor activity, anxiety-, and fear memory-related behaviors |
| Authors: | Nebuka, Mao Browse this author | | Ohmura, Yu Browse this author →KAKEN DB | | Izawa, Shuntaro Browse this author | | Bouchekioua, Youcef Browse this author →KAKEN DB | | Nishitani, Naoya Browse this author | | Yoshida, Takayuki Browse this author →KAKEN DB | | Yoshioka, Mitsuhiro Browse this author →KAKEN DB |
| Keywords: | Htr2c | | 5-HT1C | | Motor activity | | Freezing behavior |
| Issue Date: | 3-Feb-2020 |
| Publisher: | Elsevier |
| Journal Title: | Behavioural brain research |
| Volume: | 379 |
| Start Page: | 112394 |
| Publisher DOI: | 10.1016/j.bbr.2019.112394 |
| Abstract: | Pharmacological studies have suggested that the serotonin 5-HT2C receptor is involved in locomotor activity, anxiety, and fear memory. However, the results of locomotor activity and anxiety in 5-HT2C receptor knockout mice have been mixed, and the effects of 5-HT2C receptor knockout on contextual fear memory have not yet been addressed. In the present study, we reconcile these inconsistent results by analyzing behavioral data in detail and by examining the effects of 5-HT2C receptor knockout on contextual fear memory. We demonstrated that the higher locomotor activity in 5-HT2C receptor knockout mice was observed only in the late phase of the test, indicating that the analyses in the previous study using the total locomotor activity would lead to variable results. Moreover, by analyzing mouse behavior in detail, we found that 5-HT2C receptor knockout mice displayed a hesitating attitude by staying in the central area as well as risk assessment behavior in the elevated plusmaze test. However, the time spent in the open arms was longer in 5-HT2C receptor knockout mice than in wildtype littermates when a zero-maze test lacking the central area was used. In the contextual fear conditioning test, 5-HT2C receptor knockout mice showed rapid within-session extinction of fear, but not between-session extinction, compared with wild-type littermates. However, this remains inconclusive because the facilitation of extinction might be confounded with higher locomotor activity in 5-HT2C receptor knockout mice. Taken together, the present results provide reasonable explanations about previous inconsistent findings and partially filled the gaps between pharmacological and genetic findings. |
| Rights: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/86505 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 大村 優
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