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Peliosis Hepatis with Chylous Ascites in a Dog

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Title: Peliosis Hepatis with Chylous Ascites in a Dog
Authors: Gulay, Kevin Christian Montecillo Browse this author
Nagata, Noriyuki Browse this author
Aoshima, Keisuke Browse this author
Shiohara, Nozomi Browse this author
Kobayashi, Atsushi Browse this author
Takiguchi, Mitsuyoshi Browse this author →KAKEN DB
Kimura, Takashi Browse this author →KAKEN DB
Keywords: ACVRL1
chylous ascites
peliosis hepatis
Issue Date: 10-Aug-2021
Publisher: Elsevier
Journal Title: Journal of comparative pathology
Volume: 187
Start Page: 63
End Page: 67
Publisher DOI: 10.1016/j.jcpa.2021.07.001
Abstract: A 6-year-old spayed female Toy Poodle dog was referred to the Hokkaido University Veterinary Teaching Hospital for abdominal distension. Abdominocentesis yielded ascitic fluid that had a mildly increased total protein concentration and a 2.7-fold higher triglyceride concentration than plasma, and was interpreted as chylous ascites. The patient had an enlarged liver, which contained multiple, small, nodular masses and cyst-like structures. Microscopically, these lesions were multifocal dilated spaces containing lymphocytes, endothelial cells, fibrin and islands of hepatocytes. Increased alpha-smooth muscle actin-positive cells were observed in hepatic sinusoids. Based on these findings, we diagnosed peliosis hepatis with chylous ascites, which is likely to have been due to lymphangiectasia and disrupted hepatic sinusoids. Neither Bartonella spp DNA nor mutations in ACVRL1 and MTM1 genes were detected, although there was a 47-fold increase in hepatic ACVRL1 expression compared with age-matched control liver. To the authors' knowledge, this is the first report of chylous ascites resulting from peliosis hepatis in any species. (C) 2021 Elsevier Ltd. All rights reserved.
Rights: ©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 青島 圭佑

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