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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
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Leptin receptor expression and its change in association with the normalization of EGF profile after seminal plasma treatment in repeat breeder dairy cows
| Title: | Leptin receptor expression and its change in association with the normalization of EGF profile after seminal plasma treatment in repeat breeder dairy cows |
| Authors: | Ninpetch, Nattapong Browse this author | | Badrakh, Dagvajamts Browse this author | | Kyaw, Hay Mar Browse this author | | Kawano, Kohei Browse this author | | Yanagawa, Yojiro Browse this author | | Nagano, Masashi Browse this author | | Katagiri, Seiji Browse this author →KAKEN DB |
| Keywords: | Epidermal growth factor (EGF) | | Leptin | | Ob-R | | Repeat breeder | | Seminal plasma |
| Issue Date: | 28-Feb-2022 |
| Publisher: | Society for Reproduction and Development（SRD） |
| Journal Title: | Journal of reproduction and development |
| Volume: | 68 |
| Issue: | 3 |
| Start Page: | 209 |
| End Page: | 215 |
| Publisher DOI: | 10.1262/jrd.2021-142 |
| Abstract: | Factors associated with high milk production levels have been linked to alterations in the endometrial epidermal growth factor (EGF) profile, a cause of reduced fertility in dairy cows. Therefore, we examined the leptin system that connects nutritional status and reproduction in dairy cattle related to reduced fertility in repeat breeder cows. Plasma leptin concentrations were measured in 18 heifers, 20 high-yielding control cows, and 26 repeat breeder cows, showing an altered EGF profile. Then, all repeat breeder cows were infused with seminal plasma (SP) into the vagina at the next estrus to normalize the EGF profile, while heifers and control cows were infused with vehicle alone. All animals were examined for EGF profiles. Eighteen repeat breeder cows, nine heifers, and nine control cows were also determined for leptin receptor (Ob-R) expression levels in the estrous cycle before and after the infusion. SP normalized the EGF profile in 53.8% of the repeat breeder cows. Leptin concentrations were similar in all groups, regardless of the treatment results for the EGF profile. In contrast, Ob-R levels in repeat breeder and control cows were similar and higher than those in heifers before SP treatment. Ob-R in repeat breeders showing a normal EGF profile after treatment decreased to an intermediate level between heifers and control cows and may provide a clue to take measures against repeat breeding in dairy cows. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86591 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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