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Hokkaido University Collection of Scholarly and Academic Papers >
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Diet-induced obesity enhances postprandial glucagon-like peptide-1 secretion in Wistar rats, but not in diabetic Goto-Kakizaki rats
| Title: | Diet-induced obesity enhances postprandial glucagon-like peptide-1 secretion in Wistar rats, but not in diabetic Goto-Kakizaki rats |
| Authors: | Pinyo, Jukkrapong Browse this author | | Hara, Hiroshi Browse this author →KAKEN DB | | Hira, Tohru Browse this author →KAKEN DB |
| Keywords: | Enteroendocrine L-cells | | Glucagon-like peptide-1 | | Glucose intolerance | | Meal tolerance test | | Obesity |
| Issue Date: | 28-Aug-2021 |
| Publisher: | Cambridge University Press |
| Journal Title: | British journal of nutrition |
| Volume: | 126 |
| Issue: | 4 |
| Start Page: | 518 |
| End Page: | 530 |
| Publisher DOI: | 10.1017/S000711452000433X |
| Abstract: | Glucagon-like peptide-1 (GLP-1) is postprandially secreted from enteroendocrine L-cells and enhances insulin secretion. Currently, it is still controversial whether postprandial GLP-1 responses are altered in obesity and diabetes. To address the issue and to find out possible factors related, we compared postprandial GLP-1 responses in normal rats and in diabetic rats chronically fed an obesogenic diet. Male Wistar rats and diabetic Goto-Kakizaki (GK) rats were fed either a control diet or a high-fat/high-sucrose (HFS, 30 % fat and 40 % sucrose) diet for 26 weeks. Meal tolerance tests were performed for monitoring postprandial responses after a liquid diet administration (62 center dot 76 kJ/kg body weight) every 4 or 8 weeks. Postprandial glucose, GLP-1 and insulin responses in Wistar rats fed the HFS diet (WH) were higher than Wistar rats fed the control diet (WC). Although GK rats fed the HFS diet (GH) had higher glycaemic responses than GK rats fed the control diet (GC), these groups had similar postprandial GLP-1 and insulin responses throughout the study. Jejunal and ileal GLP-1 contents were increased by the HFS diet only in Wistar rats. Furthermore, mRNA expression levels of fatty acid receptors (Ffar1) in the jejunum were mildly (P = 0 center dot 053) increased by the HFS diet in Wistar rats, but not in GK rats. These results demonstrate that postprandial GLP-1 responses are enhanced under an obesogenic status in normal rats, but not in diabetic rats. Failure of adaptive enhancement of GLP-1 response in GK rats could be partly responsible for the development of glucose intolerance. |
| Rights: | © The Author(s), 2020. Published by Cambridge University Press on behalf of The Nutrition Society |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86609 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 比良 徹
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