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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
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Characterization of mucin gene expression and goblet cell proportion in inflammatory colorectal polyps in miniature dachshunds
| Title: | Characterization of mucin gene expression and goblet cell proportion in inflammatory colorectal polyps in miniature dachshunds |
| Authors: | NAGATA, Noriyuki Browse this author | | OHTA, Hiroshi Browse this author | | YOKOYAMA, Nozomu Browse this author | | Bin TEOH, Yong Browse this author | | SASAKI, Noboru Browse this author →KAKEN DB | | NAKAMURA, Kensuke Browse this author →KAKEN DB | | TAKIGUCHI, Mitsuyoshi Browse this author →KAKEN DB |
| Keywords: | canine | | goblet cell | | inflammatory colorectal polyp | | mucin |
| Issue Date: | 18-Jun-2022 |
| Publisher: | 公益社団法人 日本獣医学会 (The Japanese Society of Veterinary Science) |
| Journal Title: | Journal of veterinary medical science |
| Volume: | 84 |
| Issue: | 6 |
| Start Page: | 872 |
| End Page: | 876 |
| Publisher DOI: | 10.1292/jvms.22-0076 |
| Abstract: | Hyperplastic goblet cells and abundant mucus are significant characteristics of inflammatory colorectal polyps (ICRPs) in miniature dachshunds. In this study, selected mucin gene expressions and goblet cell proportions were evaluated in miniature dachshunds with ICRPs and in healthy dogs. Mucin 2 (MUC2) gene expression was not significantly different among the groups, whereas mucin 5AC (MUC5AC) gene expression was significantly higher in the polypoid lesions than in healthy colonic mucosa. Although the percentage of goblet cells in the upper crypt regions did not significantly differ between the groups, that in the lower crypt regions was significantly decreased in polypoid lesions. In conclusion, increased MUC5AC gene expression and goblet cell proportion changes may be associated with the pathogenesis of ICRPs. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86653 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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