| Title: | Amide proton transfer imaging for the determination of human papillomavirus status in patients with oropharyngeal squamous cell carcinoma |
| Authors: | Fujima, Noriyuki Browse this author →KAKEN DB |
| Shimizu, Yukie Browse this author |
| Yoneyama, Masami Browse this author |
| Nakagawa, Junichi Browse this author |
| Kameda, Hiroyuki Browse this author |
| Harada, Taisuke Browse this author |
| Hamada, Seijiro Browse this author |
| Suzuki, Takayoshi Browse this author |
| Tsushima, Nayuta Browse this author |
| Kano, Satoshi Browse this author →KAKEN DB |
| Homma, Akihiro Browse this author →KAKEN DB |
| Kudo, Kohsuke Browse this author →KAKEN DB |
| Issue Date: | Jul-2022 |
| Publisher: | Lippincott Williams & Wilkins (LWW) |
| Journal Title: | Medicine |
| Volume: | 101 |
| Issue: | 28 |
| Start Page: | e29457 |
| Publisher DOI: | 10.1097/MD.0000000000029457 |
| Abstract: | The aim of this study was to investigate the utility of amide proton transfer (APT) imaging for the determination of human papillomavirus (HPV) status in patients with oropharyngeal squamous cell carcinoma (SCC). Thirty-one patients with oropharyngeal SCC were retrospectively evaluated. All patients underwent amide proton transfer imaging using a 3T magnetic resonance (MR) unit. Patients were divided into HPV-positive and -negative groups depending on the pathological findings in their primary tumor. In APT imaging, the primary tumor was delineated with a polygonal region of interest (ROI). Signal information in the ROI was used to calculate the mean, standard deviation (SD) and coefficient of variant (CV) of the APT signals (APT mean, APT SD, and APT CV, respectively). The value of APT CV in the HPV-positive group (0.43 +/- 0.04) was significantly lower than that in the HPV-negative group (0.48 +/- 0.04) (P = .01). There was no significant difference in APT mean (P = .82) or APT SD (P = .13) between the HPV-positive and -negative groups. Receiver operating characteristic (ROC) curve analysis of APT CV had a sensitivity of 0.75, specificity of 0.8, positive predictive value of 0.75, negative predictive value of 0.8, accuracy of 0.77 and area under the curve (AUC) of 0.8. The APT signal in the HPV-negative group was considered heterogeneous compared to the HPV-positive group. This information might be useful for the determination of HPV status in patients with oropharyngeal SCC. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86785 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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