HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

A novel system for analyzing indocyanine green (ICG) fluorescence spectra enables deeper lung tumor localization during thoracoscopic surgery

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: A novel system for analyzing indocyanine green (ICG) fluorescence spectra enables deeper lung tumor localization during thoracoscopic surgery
Authors: Chiba, Ryohei Browse this author
Ebihara, Yuma Browse this author →KAKEN DB
Haruhiko, Shiiya Browse this author
Ujiie, Hideki Browse this author
Fujiwara-Kuroda, Aki Browse this author
Kaga, Kichizo Browse this author
Li, Liming Browse this author
Wakasa, Satoru Browse this author →KAKEN DB
Hirano, Satoshi Browse this author →KAKEN DB
Kato, Tatsuya Browse this author
Keywords: Indocyanine green (ICG)
fluorescence spectroscopy system
tumor localization
near-infrared fluorescence imaging (NIR fluorescence imaging)
Issue Date: Aug-2022
Publisher: AME Publishing Company
Journal Title: Journal of Thoracic Disease
Volume: 14
Issue: 8
Start Page: 2943
End Page: 2952
Publisher DOI: 10.21037/jtd-22-244
Abstract: Background: Palpation of tumors during thoracoscopic surgery remains difficult, and identification of deep-seated tumors may be impossible. This preclinical study investigated the usefulness of a novel indocyanine green (ICG) fluorescence spectroscopy system for tumor localization. Methods: ICG was diluted to 5.0x10(-2 )mg/mL in fetal bovine serum (FBS) and mixed with silicone resin to prepare pseudo-tumors. Sponges of different densities and a porcine lung were placed on top of the pseudo-tumors, which were examined using a novel fluorescence spectroscopy system and a near-infrared (NIR) camera. Spectra were measured for different sponge and lung thicknesses, and the lung spectra were measured during both inflation and deflation. Results: The fluorescence spectroscopy system was able to identify tumors at depths >= 15 mm, while the NIR system was not. The spectroscopy system also detected tumors at greater depths when the density of the intervening material was lower. Depending on the density and thickness of the intervening material, the system could detect spectra as deep as 40 mm for sponges and 30 mm for lungs. Conclusions: This new fluorescence spectroscopy system can be used to identify lung tumors up to a depth of 30 mm in experiments using pseudo-tumors and a porcine lung, which may aid in tumor identification during thoracoscopic surgery.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University