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A novel system for analyzing indocyanine green (ICG) fluorescence spectra enables deeper lung tumor localization during thoracoscopic surgery
| Title: | A novel system for analyzing indocyanine green (ICG) fluorescence spectra enables deeper lung tumor localization during thoracoscopic surgery |
| Authors: | Chiba, Ryohei Browse this author | | Ebihara, Yuma Browse this author →KAKEN DB | | Haruhiko, Shiiya Browse this author | | Ujiie, Hideki Browse this author | | Fujiwara-Kuroda, Aki Browse this author | | Kaga, Kichizo Browse this author | | Li, Liming Browse this author | | Wakasa, Satoru Browse this author →KAKEN DB | | Hirano, Satoshi Browse this author →KAKEN DB | | Kato, Tatsuya Browse this author |
| Keywords: | Indocyanine green (ICG) | | fluorescence spectroscopy system | | tumor localization | | near-infrared fluorescence imaging (NIR fluorescence imaging) |
| Issue Date: | Aug-2022 |
| Publisher: | AME Publishing Company |
| Journal Title: | Journal of Thoracic Disease |
| Volume: | 14 |
| Issue: | 8 |
| Start Page: | 2943 |
| End Page: | 2952 |
| Publisher DOI: | 10.21037/jtd-22-244 |
| Abstract: | Background: Palpation of tumors during thoracoscopic surgery remains difficult, and identification of deep-seated tumors may be impossible. This preclinical study investigated the usefulness of a novel indocyanine green (ICG) fluorescence spectroscopy system for tumor localization. Methods: ICG was diluted to 5.0x10(-2 )mg/mL in fetal bovine serum (FBS) and mixed with silicone resin to prepare pseudo-tumors. Sponges of different densities and a porcine lung were placed on top of the pseudo-tumors, which were examined using a novel fluorescence spectroscopy system and a near-infrared (NIR) camera. Spectra were measured for different sponge and lung thicknesses, and the lung spectra were measured during both inflation and deflation. Results: The fluorescence spectroscopy system was able to identify tumors at depths >= 15 mm, while the NIR system was not. The spectroscopy system also detected tumors at greater depths when the density of the intervening material was lower. Depending on the density and thickness of the intervening material, the system could detect spectra as deep as 40 mm for sponges and 30 mm for lungs. Conclusions: This new fluorescence spectroscopy system can be used to identify lung tumors up to a depth of 30 mm in experiments using pseudo-tumors and a porcine lung, which may aid in tumor identification during thoracoscopic surgery. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86788 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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