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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Subjects with bipolar disorder showed different reward system activation than subjects with major depressive disorder in the monetary incentive delay task
| Title: | Subjects with bipolar disorder showed different reward system activation than subjects with major depressive disorder in the monetary incentive delay task |
| Authors: | Wakatsuki, Yumi Browse this author | | Ogura, Yukiko Browse this author | | Hashimoto, Naoki Browse this author | | Toyomaki, Atsuhito Browse this author | | Miyamoto, Tamaki Browse this author | | Nakagawa, Shin Browse this author | | Inoue, Takeshi Browse this author | | Kusumi, Ichiro Browse this author →KAKEN DB |
| Keywords: | anterior insula | | bipolar disorder | | functional MRI | | major depressive disorder | | monetary incentive delay |
| Issue Date: | Aug-2022 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Psychiatry and clinical neurosciences |
| Volume: | 76 |
| Issue: | 8 |
| Start Page: | 393 |
| End Page: | 400 |
| Publisher DOI: | 10.1111/pcn.13429 |
| Abstract: | Background Differentiating between bipolar disorder (BD) and major depressive disorder (MDD) during the depressive episode is an important clinical challenge. Reward system abnormalities have received much attention as one of the biological underpinnings of BD and MDD, but few studies have directly compared these abnormalities in remitted and depressed states. Methods This was a functional MRI study using the Monetary Incentive Delay task in 65 patients (BD [n = 33], MDD [n = 32]) and 33 healthy controls (HC). Regions of interest (ROI) analysis with 21 ROIs related to reward anticipation and 17 ROIs related to gain outcome were implemented, as well as whole-brain analysis. The difference in the dimensional effect of depression on brain activation was also examined. Results Relative to the HC group, BD patients showed significantly decreased activation during reward anticipation in the anterior cingulate cortex, anterior insula (AI), and putamen, and MDD patients showed significantly decreased activation in the AI and brainstem. The dimensional effect of depression severity showed a trend-level difference between BD and MDD in the right brainstem and left AI. Conclusions The current study showed a possible differential effect of depression on the reward system between MDD and BD. Further studies on reward systems might offer reliable markers to distinguish between MDD and BD patients in the depressive phase. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86793 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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