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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings
| Title: | The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings |
| Authors: | Li, Xinnan Browse this author | | Abiko, Kagari Browse this author | | Sheriff, Sulaiman Browse this author | | Maudsley, Andrew A. Browse this author | | Urushibata, Yuta Browse this author | | Ahn, Sinyeob Browse this author | | Tha, Khin Khin Browse this author →KAKEN DB |
| Keywords: | echo-planar | | magnetic resonance spectroscopic imaging | | metabolite | | whole-brain |
| Issue Date: | Jun-2022 |
| Publisher: | MDPI |
| Journal Title: | Metabolites |
| Volume: | 12 |
| Issue: | 6 |
| Start Page: | 543 |
| Publisher DOI: | 10.3390/metabo12060543 |
| Abstract: | This prospective study aimed to evaluate the variation in magnetic resonance spectroscopic imaging (MRSI)-observed brain metabolite concentrations according to anatomical location, sex, and age, and the relationships among regional metabolite distributions, using short echo time (TE) whole-brain MRSI (WB-MRSI). Thirty-eight healthy participants underwent short TE WB-MRSI. The major metabolite ratios, i.e., N-acetyl aspartate (NAA)/creatine (Cr), choline (Cho)/Cr, glutamate + glutamine (Glx)/Cr, and myoinositol (mI)/Cr, were calculated voxel-by-voxel. Their variations according to anatomical regions, sex, and age, and their relationship to each other were evaluated by using repeated-measures analysis of variance, t-tests, and Pearson's product-moment correlation analyses. All four metabolite ratios exhibited widespread regional variation across the cerebral hemispheres (corrected p < 0.05). Laterality between the two sides and sex-related variation were also shown (p < 0.05). In several regions, NAA/Cr and Glx/Cr decreased and mI/Cr increased with age (corrected p < 0.05). There was a moderate positive correlation between NAA/Cr and mI/Cr in the insular lobe and thalamus and between Glx/Cr and mI/Cr in the parietal lobe (r >= 0.348, corrected p <= 0.025). These observations demand age- and sex- specific regional reference values in interpreting these metabolites, and they may facilitate the understanding of glial-neuronal interactions in maintaining homeostasis. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86798 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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