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Evaluation of the risk of metachronous multiple squamous cell carcinoma of the head and neck after transoral surgery based on the genetic polymorphisms of alcohol dehydrogenase 1B and aldehyde dehydrogenase 2
| Title: | Evaluation of the risk of metachronous multiple squamous cell carcinoma of the head and neck after transoral surgery based on the genetic polymorphisms of alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 |
| Authors: | Inoue, Masaki Browse this author | | Shimizu, Yuichi Browse this author →KAKEN DB | | Taniguchi, Masanobu Browse this author | | Kimura, Yuki Browse this author | | Furuhashi, Hiroto Browse this author | | Dobashi, Akira Browse this author | | Ikeya, Takashi Browse this author | | Goda, Kenichi Browse this author | | Kato, Masayuki Browse this author | | Kato, Mototsugu Browse this author | | Sakamoto, Naoya Browse this author →KAKEN DB | | Watanabe, Akihito Browse this author |
| Issue Date: | 1-Oct-2021 |
| Publisher: | Oxford University Press |
| Journal Title: | Carcinogenesis |
| Volume: | 42 |
| Issue: | 10 |
| Start Page: | 1232 |
| End Page: | 1238 |
| Publisher DOI: | 10.1093/carcin/bgab085 |
| Abstract: | Patients with superficial head and neck squamous cell carcinoma (HNSCC) can be completely treated by techniques of transoral surgery (TOS). The aim of this study was to evaluate the risk of metachronous multiple HNSCC arising after TOS based on alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2). We registered patients who underwent TOS for superficial HNSCC. Buccal cell samples were obtained by using a cotton swab to examine two single nucleotide polymorphisms in ADH1B and ALDH2 genotyping. We used Cox proportional hazards models to examine the risk of metachronous HNSCC. A total of 198 patients who underwent TOS for HNSCC were evaluated. In multivariate analysis, risks for second HNSCC were ADH1B*1/*1 [hazard ratio (HR), 1.88; 95% confidence interval (CI), 1.11-3.19; P = 0.02], ALDH2*1/*2 (HR, 2.11; 95% CI, 1.00-5.16; P = 0.048) and alcohol consumption before TOS (HR, 1.17; 95% CI, 1.06-1.27; P = 0.01). The 5-year incidence rates of second primary HNSCC in the temperance group and the non-temperance group were 20.8 and 46.5%, respectively (HR, 0.54; 95% CI, 0.31-0.92; P = 0.02). Cumulative development rates of third HNSCC in the temperance group and non-temperance group at 10 years were 11.3 and 36.1%, respectively (HR, 0.19; 95% CI, 0.03-0.65; P = 0.006). ADH1B*1/*1, ALDH2*1/*2 and moderate or heavy alcohol consumption before treatment are independent risk factors of metachronous HNSCC. Since it was shown that temperance decreased the incidences of second and third metachronous HNSCC, advice to discontinue alcohol drinking is necessary. |
| Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in Carcinogenesis following peer review. The version of record Masaki Inoue, Yuichi Shimizu, Masanobu Taniguchi, Yuki Kimura, Hiroto Furuhashi, Akira Dobashi, Takashi Ikeya, Kenichi Goda, Masayuki Kato, Mototsugu Kato, Naoya Sakamoto, Akihito Watanabe, Evaluation of the risk of metachronous multiple squamous cell carcinoma of the head and neck after transoral surgery based on the genetic polymorphisms of alcohol dehydrogenase 1B and aldehyde dehydrogenase 2, Carcinogenesis, Volume 42, Issue 10, October 2021, Pages 1232–1238 is available online at: https://doi.org/10.1093/carcin/bgab085. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/86819 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 清水 勇一
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