Efficient synthesis of α,β-dichlorinated ketones from α,β-dichlorinated Weinreb amides through a simple work-up procedure


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Org.Biomol.Chem.v19(36)2021.pdf		287.31 kB	PDF	View/Open
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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/86845

Title:	Efficient synthesis of α,β-dichlorinated ketones from α,β-dichlorinated Weinreb amides through a simple work-up procedure
Authors:	Prakoso, Nurcahyo Iman Browse this author
	Matsuda, Fuyuhiko Browse this author →KAKEN DB
	Umezawa, Taiki Browse this author →KAKEN DB
Issue Date:	28-Sep-2021
Publisher:	Royal Society of Chemistry
Journal Title:	Organic & Biomolecular Chemistry
Volume:	19
Issue:	36
Start Page:	7822
End Page:	7826
Publisher DOI:	10.1039/d1ob01379c
Abstract:	An efficient synthesis of α,β-dichlorinated ketones from α,β-dichlorinated Weinreb amides is described. Quenching with nonaqueous HCl avoided side reactions associated with typical work-up procedures. The amide reacted with various nucleophiles to give the corresponding ketones in high yields. A novel reactivity of the Weinreb amide is also discussed.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/86845
Appears in Collections:	環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 梅澤大樹

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