Fabrication and cell behavior assessment of antibacterial micro/nano-patterned chitosan films


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2022 Nishida Nano Biomed.pdf

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/86856

Title:	Fabrication and cell behavior assessment of antibacterial micro/nano-patterned chitosan films
Authors:	Nishida, Erika Browse this author →KAKEN DB
	Miyaji, Hirofumi Browse this author →KAKEN DB
	Sugaya, Tsutomu Browse this author →KAKEN DB
	Akasaka, Tsukasa Browse this author →KAKEN DB
Keywords:	biomaterial surfaces
	chitosan
	Streptococcus mutans
	MC3T3-E1 cell
Issue Date:	Jun-2022
Journal Title:	Nano Biomedicine
Volume:	14
Issue:	1
Start Page:	1
End Page:	8
Publisher DOI:	10.11344/nano.14.1
Abstract:	The surface of biomaterials with a fine micro/nano-pattern reportedly affects cell behavior. Chitosan was previously shown to exhibit antibacterial properties and thus here we evaluated the cellular response and antibacterial activity of chitosan micro/nano patterns prepared by the imprint method. We fabricated micro/nano patterns with different sizes and shapes of pillars, grooves, and holes. The chitosan pattern films exhibited antibacterial activity towards Streptococcus mutans. In addition, we observed mammalian cells adhering to and spreading on the chitosan pattern, and found that the orientation of the cells was controlled by the shape of the pattern.
Type:	article
URI:	http://hdl.handle.net/2115/86856
Appears in Collections:	歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治裕史

OAI-PMH ( junii2 , jpcoar_1.0 )

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