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Salivary Biomarker Profiles and Chronic Fatigue among Nurses Working Rotation Shifts : An Exploratory Pilot Study

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Title: Salivary Biomarker Profiles and Chronic Fatigue among Nurses Working Rotation Shifts : An Exploratory Pilot Study
Authors: Yamaguchi, Shinya Browse this author
Watanabe, Kazuhiro Browse this author
Sugimura, Naotaka Browse this author
Shishido, Inaho Browse this author →KAKEN DB
Konya, Issei Browse this author
Fujita, Tomoko Browse this author
Yoshimitsu, Yuichi Browse this author
Kato, Shintaro Browse this author
Ito, Yoichi M. Browse this author →KAKEN DB
Yano, Rika Browse this author →KAKEN DB
Keywords: nurses
shift work schedule
Issue Date: 28-Jul-2022
Publisher: MDPI
Journal Title: Healthcare
Volume: 10
Issue: 8
Start Page: 1416
Publisher DOI: 10.3390/healthcare10081416
PMID: 36011073
Abstract: Although nurses' fatigue affects their well-being and patient safety, no effective objective measurements exist. We explored the profiles of salivary biomarkers associated with nurses' chronic fatigue across several shifts. This longitudinal study involved 45 shiftwork nurses and collected their saliva samples before two night and two day shifts for a month. Chronic fatigue was measured using the Cumulative Fatigue Symptom Index before the first night shift. Biomarker profiles were analyzed using hierarchical cluster analysis, and chronic fatigue levels were compared between the profiles. Cortisol profiles were classified into high- and low-level groups across two day shifts; the low-level group presented significantly higher irritability and unwillingness to work. Secretory immunoglobulin A (s-IgA) profiles across the four shifts were classified into high- and low-level groups; the high-level group had significantly higher depressive feelings, decreased vitality, irritability, and unwillingness to work. Cortisol (two day shifts) and s-IgA (four shifts) profiles were combined, and (i) cortisol low-level and s-IgA high-level and (ii) cortisol high-level and s-IgA low-level groups were identified. The former group had significantly higher chronic fatigue sign and irritability than the latter group. The profiles of salivary cortisol and s-IgA across several shifts were associated with nurses' chronic fatigue.
Type: article
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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