| Title: | Associations between prenatal exposure to organochlorine pesticides and thyroid hormone levels in mothers and infants : The Hokkaido study on environment and children's health |
| Authors: | Yamazaki, Keiko Browse this author →KAKEN DB |
| Itoh, Sachiko Browse this author →KAKEN DB |
| Araki, Atsuko Browse this author →KAKEN DB |
| Miyashita, Chihiro Browse this author →KAKEN DB |
| Minatoya, Machiko Browse this author →KAKEN DB |
| Ikeno, Tamiko Browse this author →KAKEN DB |
| Kato, Shizue Browse this author |
| Fujikura, Kaori Browse this author |
| Mizutani, Futoshi Browse this author |
| Chisaki, Yoichi Browse this author |
| Kishi, Reiko Browse this author →KAKEN DB |
| Keywords: | Thyroid hormone |
| Organochlorine pesticides |
| Pregnancy exposure |
| Birth cohort |
| Issue Date: | Oct-2020 |
| Publisher: | Elsevier |
| Journal Title: | Environmental research |
| Volume: | 189 |
| Start Page: | 109840 |
| Publisher DOI: | 10.1016/j.envres.2020.109840 |
| Abstract: | Organochlorine pesticides (OCPs) are environmental contaminants with potentially adverse effects on neurodevelopment. Previous findings on the association between prenatal exposure to OCPs and the maternal or infant thyroid hormone system are inconsistent. Moreover, the influence of exposure to multiple OCPs and other chemical compounds is not clearly understood. Our study therefore aimed to examine the association between OCP exposure and both maternal and infant thyroid hormone systems. We also explored multiple exposure effects of OCPs and the influence of each compound using weighted quantile sum (WQS) methods. The study population included 514 participants in the Hokkaido study, recruited from 2002 to 2005 at one hospital in Sapporo, Japan. To quantify 29 OCPs, maternal blood samples were analyzed using gas chromatography/mass spectrometry. Blood samples for measuring thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were obtained from mothers during the early gestational stage (mean 11.4 weeks), and from infants between 7 and 43 days of age. The data of 333 mother child pairs with OCP and thyroid hormone measurements were included in the final analyses. Multivariate regression models showed a negative association between maternal FT4 and levels of o,p -dichlorodiphenyldichloroethylene (DDE), o,p'-dichlorodiphenyltrichlomethane (DDT), and dieldrin. The WQS analysis showed that o,p '-DDT (48.6%), cis-heptachlorepoxide (22.8%), dieldrin (15.4%) were the primary contributors to the significant multiple exposure effect of OCPs on maternal FT4. For infants, we found a positive association between FT4 and cis-nonachlor and mirex. The most contributory compounds in the multiple exposure effect were trans-nonachlor (27.1%) and cis-nonachlor (13.8%), while several compounds contributed to the WQS via small weights (0.4-9.1%). These results indicate that OCPs, even at very low levels, may influence maternal and child thyroid hormone levels, which could modulate child development. |
| Rights: | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/86881 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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