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Associations between prenatal exposure to organochlorine pesticides and thyroid hormone levels in mothers and infants : The Hokkaido study on environment and children's health

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Title: Associations between prenatal exposure to organochlorine pesticides and thyroid hormone levels in mothers and infants : The Hokkaido study on environment and children's health
Authors: Yamazaki, Keiko Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Minatoya, Machiko Browse this author →KAKEN DB
Ikeno, Tamiko Browse this author →KAKEN DB
Kato, Shizue Browse this author
Fujikura, Kaori Browse this author
Mizutani, Futoshi Browse this author
Chisaki, Yoichi Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Thyroid hormone
Organochlorine pesticides
Pregnancy exposure
Birth cohort
Issue Date: Oct-2020
Publisher: Elsevier
Journal Title: Environmental research
Volume: 189
Start Page: 109840
Publisher DOI: 10.1016/j.envres.2020.109840
Abstract: Organochlorine pesticides (OCPs) are environmental contaminants with potentially adverse effects on neurodevelopment. Previous findings on the association between prenatal exposure to OCPs and the maternal or infant thyroid hormone system are inconsistent. Moreover, the influence of exposure to multiple OCPs and other chemical compounds is not clearly understood. Our study therefore aimed to examine the association between OCP exposure and both maternal and infant thyroid hormone systems. We also explored multiple exposure effects of OCPs and the influence of each compound using weighted quantile sum (WQS) methods. The study population included 514 participants in the Hokkaido study, recruited from 2002 to 2005 at one hospital in Sapporo, Japan. To quantify 29 OCPs, maternal blood samples were analyzed using gas chromatography/mass spectrometry. Blood samples for measuring thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were obtained from mothers during the early gestational stage (mean 11.4 weeks), and from infants between 7 and 43 days of age. The data of 333 mother child pairs with OCP and thyroid hormone measurements were included in the final analyses. Multivariate regression models showed a negative association between maternal FT4 and levels of o,p -dichlorodiphenyldichloroethylene (DDE), o,p'-dichlorodiphenyltrichlomethane (DDT), and dieldrin. The WQS analysis showed that o,p '-DDT (48.6%), cis-heptachlorepoxide (22.8%), dieldrin (15.4%) were the primary contributors to the significant multiple exposure effect of OCPs on maternal FT4. For infants, we found a positive association between FT4 and cis-nonachlor and mirex. The most contributory compounds in the multiple exposure effect were trans-nonachlor (27.1%) and cis-nonachlor (13.8%), while several compounds contributed to the WQS via small weights (0.4-9.1%). These results indicate that OCPs, even at very low levels, may influence maternal and child thyroid hormone levels, which could modulate child development.
Rights: © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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