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Genotyping of Theileria parva populations in vaccinated and non-vaccinated cattle in Malawi

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Title: Genotyping of Theileria parva populations in vaccinated and non-vaccinated cattle in Malawi
Authors: Chatanga, Elisha Browse this author
Ohari, Yuma Browse this author
Muleya, Walter Browse this author
Hayashida, Kyoko Browse this author
Sugimoto, Chihiro Browse this author
Katakura, Ken Browse this author →KAKEN DB
Nonaka, Nariaki Browse this author →KAKEN DB
Nakao, Ryo Browse this author →KAKEN DB
Keywords: Genotyping
population structure
Theileria parva
Issue Date: 11-Apr-2022
Publisher: Cambridge University Press
Journal Title: Parasitology
Volume: 149
Issue: 7
Start Page: 983
End Page: 990
Publisher DOI: 10.1017/S0031182022000464
Abstract: Theileria parva is an apicomplexan protozoan parasite that causes bovine theileriosis (East Coast Fever; ECF) in central, eastern and southern Africa. In Malawi, ECF is endemic in the northern and central regions where it has negatively affected the development of dairy industry. Despite its endemic status the genetic population structure of T. parva in Malawi is currently unknown. To obtain an understanding of T. parva in Malawi, we performed population genetics analysis of T. parva populations in cattle vaccinated with the Muguga cocktail live vaccine and non-vaccinated cattle using mini- and microsatellite markers covering all the four T. parva chromosomes. The T. parva Muguga strain was included in this study as a reference strain. Linkage disequilibrium was observed when all samples were treated as a single population. There was sub-structuring among the samples as shown by the principal coordinate analysis. Majority of the samples clustered with the T. parva Muguga reference strain suggesting that the isolates in Malawi are closely related to the vaccine component, which support the current use of Muguga cocktail vaccine to control ECF. The clustering of samples from non-endemic southern region with those from endemic central region suggests expansion of the distribution of T. parva in Malawi.
Rights: This article has been published in a revised form in Parasitology []. This version is free to view and download for private research and study only. Not for re-distribution or re-use. © copyright holder.
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中尾 亮

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