|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences >
Peer-reviewed Journal Articles, etc >
Preparation of Apoastaxanthinals and Evaluation of Their Anti-inflammatory Action against Lipopolysaccharide-Stimulated Macrophages and Adipocytes
| Title: | Preparation of Apoastaxanthinals and Evaluation of Their Anti-inflammatory Action against Lipopolysaccharide-Stimulated Macrophages and Adipocytes |
| Authors: | Takatani, Naoki Browse this author →KAKEN DB | | Beppu, Fumiaki Browse this author →KAKEN DB | | Yamano, Yumiko Browse this author →KAKEN DB | | Maoka, Takashi Browse this author →KAKEN DB | | Miyashita, Kazuo Browse this author →KAKEN DB | | Hosokawa, Masashi Browse this author →KAKEN DB |
| Issue Date: | 13-Oct-2022 |
| Publisher: | American Chemical Society |
| Journal Title: | ACS Omega |
| Volume: | 7 |
| Issue: | 26 |
| Start Page: | 22061 |
| End Page: | 22986 |
| Publisher DOI: | 10.1021/acsomega.2c01164 |
| Abstract: | Apocarotenoids are carotenoid derivatives in which the polyene chain is cleaved via enzymatic or nonenzymatic action. They are found in animal tissues and carotenoid-containing foods. However, limited information on the biological functions of apocarotenoids is available. Here, we prepared apocarotenoids from astaxanthin via chemical oxidation and evaluated their anti-inflammatory action against macrophages and adipocytes. A series of astaxanthin-derived apoastaxanthinals, apo-11-, apo-15-, apo-14'-, apo-12'-, apo-10'-, and apo-8'astaxanthinals, were successfully characterized by chromatography and spectroscopic analysis. The apoastaxanthinals inhibited inflammatory cytokine production and mRNA expression against lipopolysaccharide-stimulated RAW 264.7 macrophages. Apoastaxanthinals suppressed interleukin-6 overexpression in an in vitro model with macrophages and adipocytes in the following cultures: (1) contact coculture of 3T3-L1 adipocytes and RAW264.7 macrophages and (2) 3T3-L1 adipocytes in a RAW264.7-derived conditioned media. These results indicate that the apoastaxanthinals have the potential for regulation of adipose tissue inflammation observed in obesity. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86942 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
