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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences >
Peer-reviewed Journal Articles, etc >
Classification of Marine Algae-Derived Compounds by the Mechanism Responsible for Decreasing Lipoxygenase-Catalyzed Lipid Hydroperoxides
| Title: | Classification of Marine Algae-Derived Compounds by the Mechanism Responsible for Decreasing Lipoxygenase-Catalyzed Lipid Hydroperoxides |
| Authors: | Kurihara, Hideyuki Browse this author →KAKEN DB | | Yachiyama, Kenta Browse this author | | Morimoto, Chihiro Browse this author |
| Keywords: | phenolics | | fucoxanthin | | pheophytin a | | lipoxygenase | | inhibitor | | lipid hydroperoxide | | decomposer marine natural products | | structure | | biosynthesis | | biological activities | | synthetic derivatives and analogs | | short communication |
| Issue Date: | Aug-2022 |
| Publisher: | SAGE Publications |
| Journal Title: | Natural product communications |
| Volume: | 17 |
| Issue: | 8 |
| Start Page: | 1934578X221115249 |
| Publisher DOI: | 10.1177/1934578X221115249 |
| Abstract: | Lipoxygenase (LOX)-mediated lipid hydroperoxides (LHPOs) are converted to physiologically active mediators. Thus, decreasing hydroperoxides is important for diminishing various health-related risks. In this study, decreasing compounds of LOX-catalyzed LHPOs were investigated and classified by mechanism using a modified triple LOX-indamine dye formation (IDF) method. The compounds 2,3-dibromo-4,5-dihydroxybenzyl methyl ether (1) and fucoxanthin (2) were isolated from algae as compounds that can decrease hydroperoxides. Along with previously isolated pheophytin a (3), a chlorophyll-related compound, and purchased nordihydroguaiaretic acid (4), a well-known lipoxygenase inhibitor, all the compounds were examined to determine the mechanisms responsible for decreasing LHPOs by using a modified triple LOX-IDF method. Compounds 1 and 4 were found to be LOX inhibitors, compound 2 was a decomposer of the produced LHPOs, and compound 3 was both an inhibitor and a decomposer of the produced LHPOs. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86947 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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