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High-fluence and high-gain multilayer focusing optics to enhance spatial resolution in femtosecond X-ray laser imaging

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Title: High-fluence and high-gain multilayer focusing optics to enhance spatial resolution in femtosecond X-ray laser imaging
Authors: Yumoto, Hirokatsu Browse this author
Koyama, Takahisa Browse this author
Suzuki, Akihiro Browse this author →KAKEN DB
Joti, Yasumasa Browse this author
Niida, Yoshiya Browse this author
Tono, Kensuke Browse this author
Bessho, Yoshitaka Browse this author
Yabashi, Makina Browse this author
Nishino, Yoshinori Browse this author →KAKEN DB
Ohashi, Haruhiko Browse this author
Issue Date: 13-Sep-2022
Publisher: Nature Portfolio
Journal Title: Nature communications
Volume: 13
Issue: 1
Start Page: 5300
Publisher DOI: 10.1038/s41467-022-33014-4
Abstract: With the emergence of X-ray free-electron lasers (XFELs), coherent diffractive imaging (CDI) has acquired a capability for single-particle imaging (SPI) of non-crystalline objects under non-cryogenic conditions. However, the single-shot spatial resolution is limited to similar to 5 nanometres primarily because of insufficient fluence. Here, we present a CDI technique whereby high resolution is achieved with very-high-fluence X-ray focusing using multilayer mirrors with nanometre precision. The optics can focus 4-keV XFEL down to 60 nm x 110 nm and realize a fluence of >3 x 10(5) J cm(-2) pulse(-1) or >4 x 10(12) photons mu m(-2) pulse(-1) with a tenfold increase in the total gain compared to conventional optics due to the high demagnification. Further, the imaging of fixed-target metallic nanoparticles in solution attained an unprecedented 2-nm resolution in single-XFEL-pulse exposure. These findings can further expand the capabilities of SPI to explore the relationships between dynamic structures and functions of native biomolecular complexes.
Type: article
Appears in Collections:電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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