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Monocaprin Enhances Bioavailability of Fucoxanthin in Diabetic/Obese KK-A(y) Mice

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Title: Monocaprin Enhances Bioavailability of Fucoxanthin in Diabetic/Obese KK-A(y) Mice
Authors: Nagata, Kodai Browse this author
Takatani, Naoki Browse this author →KAKEN DB
Beppu, Fumiaki Browse this author →KAKEN DB
Abe, Aya Browse this author
Tominaga, Etsuko Browse this author
Fukuhara, Tomohisa Browse this author
Ozeki, Makoto Browse this author
Hosokawa, Masashi Browse this author →KAKEN DB
Keywords: fucoxanthin
monocaprin
bioavailability
fucoxanthinol
Issue Date: Jul-2022
Publisher: MDPI
Journal Title: Marine drugs
Volume: 20
Issue: 7
Start Page: 446
Publisher DOI: 10.3390/md20070446
Abstract: Fucoxanthin is a marine carotenoid found in brown seaweeds and several microalgae. It has been reported that fucoxanthin has health benefits such as anti-obesity and anti-diabetic effects. To facilitate fucoxanthin applications in the food industry, it is important to improve its low bioavailability. We attempted the combined feeding of fucoxanthin-containing seaweed oil (SO) and monocaprin in a powder diet and analyzed the fucoxanthin metabolite contents in the liver, small intestine and serum of diabetic/obese KK-A(y) mice. After 4 weeks of feeding with the experimental diets, the serum fucoxanthinol concentrations of the mice fed 0.2% SO and 0.5% monocaprin were higher than those of the 0.2% SO-fed mice. Furthermore, fucoxanthinol accumulation in the liver and small intestine tended to increase in a combination diet of 0.2% SO and 0.125-0.5% monocaprin compared with a diet of 0.2% SO alone, although amarouciaxanthin A accumulation was not different among the 0.2% SO-fed groups. These results suggest that a combination of monocaprin with fucoxanthin-containing SO is an effective treatment for improving the bioavailability of fucoxanthin.
Type: article
URI: http://hdl.handle.net/2115/86982
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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