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Monocaprin Enhances Bioavailability of Fucoxanthin in Diabetic/Obese KK-A(y) Mice
Title: | Monocaprin Enhances Bioavailability of Fucoxanthin in Diabetic/Obese KK-A(y) Mice |
Authors: | Nagata, Kodai Browse this author | Takatani, Naoki Browse this author →KAKEN DB | Beppu, Fumiaki Browse this author →KAKEN DB | Abe, Aya Browse this author | Tominaga, Etsuko Browse this author | Fukuhara, Tomohisa Browse this author | Ozeki, Makoto Browse this author | Hosokawa, Masashi Browse this author →KAKEN DB |
Keywords: | fucoxanthin | monocaprin | bioavailability | fucoxanthinol |
Issue Date: | Jul-2022 |
Publisher: | MDPI |
Journal Title: | Marine drugs |
Volume: | 20 |
Issue: | 7 |
Start Page: | 446 |
Publisher DOI: | 10.3390/md20070446 |
Abstract: | Fucoxanthin is a marine carotenoid found in brown seaweeds and several microalgae. It has been reported that fucoxanthin has health benefits such as anti-obesity and anti-diabetic effects. To facilitate fucoxanthin applications in the food industry, it is important to improve its low bioavailability. We attempted the combined feeding of fucoxanthin-containing seaweed oil (SO) and monocaprin in a powder diet and analyzed the fucoxanthin metabolite contents in the liver, small intestine and serum of diabetic/obese KK-A(y) mice. After 4 weeks of feeding with the experimental diets, the serum fucoxanthinol concentrations of the mice fed 0.2% SO and 0.5% monocaprin were higher than those of the 0.2% SO-fed mice. Furthermore, fucoxanthinol accumulation in the liver and small intestine tended to increase in a combination diet of 0.2% SO and 0.125-0.5% monocaprin compared with a diet of 0.2% SO alone, although amarouciaxanthin A accumulation was not different among the 0.2% SO-fed groups. These results suggest that a combination of monocaprin with fucoxanthin-containing SO is an effective treatment for improving the bioavailability of fucoxanthin. |
Type: | article |
URI: | http://hdl.handle.net/2115/86982 |
Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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