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Hokkaido University Collection of Scholarly and Academic Papers >
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Sustained antibacterial coating with graphene oxide ultrathin film combined with cationic surface-active agents in a wet environment
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Sustained antibacterial coating with graphene oxide ultrathin film combined with cationic surface-active agents in a wet environment |
| Authors: | Miyaji, Hirofumi Browse this author →KAKEN DB | | Kanemoto, Yukimi Browse this author | | Hamamoto, Asako Browse this author | | Shitomi, Kanako Browse this author →KAKEN DB | | Nishida, Erika Browse this author →KAKEN DB | | Kato, Akihito Browse this author →KAKEN DB | | Sugaya, Tsutomu Browse this author →KAKEN DB | | Tanaka, Saori Browse this author →KAKEN DB | | Aikawa, Natsuha Browse this author | | Kawasaki, Hideya Browse this author →KAKEN DB | | Gohda, Syun Browse this author | | Ono, Hironobu Browse this author |
| Issue Date: | 18-Oct-2022 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Scientific Reports |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 16721 |
| Publisher DOI: | 10.1038/s41598-022-21205-4 |
| PMID: | 36257962 |
| Abstract: | Antimicrobial surfactants contained in mouthrinse have excellent efficacy, but are not retained on the tooth surface (are rinsed away) due to their low water resistance and thus do not exhibit sustained antibacterial activity. We have developed a new coating method using graphene oxide (GO) that retains the surfactant on the tooth surface even after rinsing with water, thus providing a sustained antibacterial effect. Ultra-thin films of GO and an antimicrobial agent were prepared by (1) applying GO to the substrate surface, drying, and thoroughly rinsing with water to remove excess GO to form an ultrathin film (almost a monolayer, transparent) on the substrate surface, then (2) applying antimicrobial cationic surface active agents (CSAAs) on the GO film to form a composite coating film (GO/CSAA). GO/CSAA formation was verified by scanning electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, and ζ-potential and contact angle measurements. GO/CSAA was effective at inhibiting the growth of oral pathogens for up to 7 days of storage in water, and antibacterial activity was recovered by reapplication of the CSAA. Antibacterial GO/CSAA films were also formed on a tooth substrate. The results suggest that GO/CSAA coatings are effective in preventing oral infections. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86986 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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