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Sustained antibacterial coating with graphene oxide ultrathin film combined with cationic surface-active agents in a wet environment

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Title: Sustained antibacterial coating with graphene oxide ultrathin film combined with cationic surface-active agents in a wet environment
Authors: Miyaji, Hirofumi Browse this author →KAKEN DB
Kanemoto, Yukimi Browse this author
Hamamoto, Asako Browse this author
Shitomi, Kanako Browse this author →KAKEN DB
Nishida, Erika Browse this author →KAKEN DB
Kato, Akihito Browse this author →KAKEN DB
Sugaya, Tsutomu Browse this author →KAKEN DB
Tanaka, Saori Browse this author →KAKEN DB
Aikawa, Natsuha Browse this author
Kawasaki, Hideya Browse this author →KAKEN DB
Gohda, Syun Browse this author
Ono, Hironobu Browse this author
Issue Date: 18-Oct-2022
Publisher: Nature Publishing Group
Journal Title: Scientific Reports
Volume: 12
Issue: 1
Start Page: 16721
Publisher DOI: 10.1038/s41598-022-21205-4
PMID: 36257962
Abstract: Antimicrobial surfactants contained in mouthrinse have excellent efficacy, but are not retained on the tooth surface (are rinsed away) due to their low water resistance and thus do not exhibit sustained antibacterial activity. We have developed a new coating method using graphene oxide (GO) that retains the surfactant on the tooth surface even after rinsing with water, thus providing a sustained antibacterial effect. Ultra-thin films of GO and an antimicrobial agent were prepared by (1) applying GO to the substrate surface, drying, and thoroughly rinsing with water to remove excess GO to form an ultrathin film (almost a monolayer, transparent) on the substrate surface, then (2) applying antimicrobial cationic surface active agents (CSAAs) on the GO film to form a composite coating film (GO/CSAA). GO/CSAA formation was verified by scanning electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, and ζ-potential and contact angle measurements. GO/CSAA was effective at inhibiting the growth of oral pathogens for up to 7 days of storage in water, and antibacterial activity was recovered by reapplication of the CSAA. Antibacterial GO/CSAA films were also formed on a tooth substrate. The results suggest that GO/CSAA coatings are effective in preventing oral infections.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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