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Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism

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Title: Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism
Authors: Nagata, Noriyuki Browse this author
Sawamura, Hiryu Browse this author
Morishita, Keitaro Browse this author
Hosoya, Kenji Browse this author
Yokoyama, Nozomu Browse this author
Sasaoka, Kazuyoshi Browse this author
Sasaki, Noboru Browse this author
Nakamura, Kensuke Browse this author
Ikenaka, Yoshinori Browse this author
Takiguchi, Mitsuyoshi Browse this author →KAKEN DB
Keywords: canine
Cushing’s syndrome
hyperadrenocorticism
urinary cortisol
Issue Date: Jul-2022
Publisher: 公益社団法人 日本獣医学会 (The Japanese Society of Veterinary Science)
Journal Title: Journal of veterinary medical science
Volume: 84
Issue: 7
Start Page: 954
End Page: 959
Publisher DOI: 10.1292/jvms.22-0131
Abstract: The urinary corticoid to creatinine ratio (UCCR) is one of the most commonly used screening tests for canine hypercortisolism (HC). In this study, a reference interval was established for UCCR using IMMULITE 2000 XPi, the latest chemiluminescence enzyme immunoassay. The diagnostic performance of this method for UCCR in canine HC was also evaluated. The median UCCR was 1.06 x 10(-5) (range: 0.28-2.49) for 58 healthy dogs, and an upper reference limit of 1.98 x 10(-5) (90% confidence interval: 1.76-2.15) was determined. The median UCCR in the 12 dogs with HC (7.38 x 10(-5), range 1.86-29.98) was significantly higher than that in the 16 dogs with mimic-HC (1.59 x 10(-5), range 0.47-3.42, P < 0.001). The area under the curve for UCCR to differentiate HC dogs from mimic-HC dogs was 0.971, with a sensitivity of 91.7% and specificity of 100% when the cut-off value was set at 3.77 x 10(-5). The UCCR of 16 paired urine samples collected at home and in hospital showed that the UCCR of samples collected in the hospital was significantly higher than that of samples collected at home (mean difference 3.30 x 10-5, 95% confidence interval: 0.70-5.90, P=0.001). In summary, we established the upper reference limit for UCCR using IMMULITE 2000 XPi in dogs and confirmed that UCCR is a useful diagnostic test for HC in dogs if urine samples are collected at home.
Type: article
URI: http://hdl.handle.net/2115/87105
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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