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Does Moringa Oleifera affect element accumulation patterns and lead toxicity in Sprague-Dawley rats?

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Title: Does Moringa Oleifera affect element accumulation patterns and lead toxicity in Sprague-Dawley rats?
Authors: Nakata, Hokuto Browse this author
Nakayama, Shouta M. M. Browse this author
Kataba, Andrew Browse this author
Toyomaki, Haruya Browse this author
Doya, Rio Browse this author
Yohannes, Yared Beyene Browse this author
Ikenaka, Yoshinori Browse this author
Ishizuka, Mayumi Browse this author →KAKEN DB
Keywords: Lead poisoning
Moringa Oleifera
Protein carbonyl
Issue Date: 1-Oct-2022
Publisher: Elsevier
Journal Title: Journal of functional foods
Volume: 97
Start Page: 105242
Publisher DOI: 10.1016/j.jff.2022.105242
Abstract: Moringa Oleifera (MO) has potential for nutritional and medical applications. We verified whether the administration of MO changed mineral accumulation patterns and mitigative effects of lead poisoning using Sprague-Dawley rats. MO leaves, aqueous leaf extracts, and seeds were administrated to rats in two different concentrations (100 and 600 mg/kg body weight/day) for 3 weeks. Element analysis, biochemical blood tests, oxidative-stress assessment, and blood delta-aminolevulinic acid dehydratase (ALAD) activity assays were performed after euthanasia and dissection. Although apparent changes in element accumulation patterns and biochemical parameters for hepatic and renal function assessments were not observed, lead-induced oxidative stress was significantly mitigated by the administration of MO leaves. The administration of high-dose MO leaves and seeds significantly recovered ALAD activity. Further investigations for potential mitigative effects of MO on lead toxicity and its mechanism are required.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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