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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Does Moringa Oleifera affect element accumulation patterns and lead toxicity in Sprague-Dawley rats?
| Title: | Does Moringa Oleifera affect element accumulation patterns and lead toxicity in Sprague-Dawley rats? |
| Authors: | Nakata, Hokuto Browse this author | | Nakayama, Shouta M. M. Browse this author | | Kataba, Andrew Browse this author | | Toyomaki, Haruya Browse this author | | Doya, Rio Browse this author | | Yohannes, Yared Beyene Browse this author | | Ikenaka, Yoshinori Browse this author | | Ishizuka, Mayumi Browse this author →KAKEN DB |
| Keywords: | Lead poisoning | | Moringa Oleifera | | Sprague-Dawley | | Protein carbonyl | | ALAD |
| Issue Date: | 1-Oct-2022 |
| Publisher: | Elsevier |
| Journal Title: | Journal of functional foods |
| Volume: | 97 |
| Start Page: | 105242 |
| Publisher DOI: | 10.1016/j.jff.2022.105242 |
| Abstract: | Moringa Oleifera (MO) has potential for nutritional and medical applications. We verified whether the administration of MO changed mineral accumulation patterns and mitigative effects of lead poisoning using Sprague-Dawley rats. MO leaves, aqueous leaf extracts, and seeds were administrated to rats in two different concentrations (100 and 600 mg/kg body weight/day) for 3 weeks. Element analysis, biochemical blood tests, oxidative-stress assessment, and blood delta-aminolevulinic acid dehydratase (ALAD) activity assays were performed after euthanasia and dissection. Although apparent changes in element accumulation patterns and biochemical parameters for hepatic and renal function assessments were not observed, lead-induced oxidative stress was significantly mitigated by the administration of MO leaves. The administration of high-dose MO leaves and seeds significantly recovered ALAD activity. Further investigations for potential mitigative effects of MO on lead toxicity and its mechanism are required. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87106 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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