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The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation

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Title: The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation
Authors: Yu, Li Browse this author
Maishi, Nako Browse this author →KAKEN DB
Akahori, Erika Browse this author
Hasebe, Akira Browse this author →KAKEN DB
Takeda, Ryo Browse this author →KAKEN DB
Matsuda, Aya Yanagawa Browse this author →KAKEN DB
Hida, Yasuhiro Browse this author →KAKEN DB
Nam, Jin-Min Browse this author →KAKEN DB
Onodera, Yasuhito Browse this author →KAKEN DB
Kitagawa, Yoshimasa Browse this author →KAKEN DB
Hida, Kyoko Browse this author →KAKEN DB
Keywords: endothelial cells
oral bacteria
oral hygiene
tumor metastasis
vascular inflammation
Issue Date: 23-Aug-2022
Publisher: John Wiley & Sons
Journal Title: Cancer science
Volume: 113
Issue: 11
Start Page: 3980
End Page: 3994
Publisher DOI: 10.1111/cas.15538
PMID: 35997541
Abstract: Recent studies have demonstrated a relationship between oral bacteria and systemic inflammation. Endothelial cells (ECs), which line blood vessels, control the opening and closing of the vascular barrier and contribute to hematogenous metastasis; however, the role of oral bacteria-induced vascular inflammation in tumor metastasis remains unclear. In this study, we examined the phenotypic changes in vascular ECs following Streptococcus mutans (S. mutans) stimulation in vitro and in vivo. The expression of molecules associated with vascular inflammation and barrier-associated adhesion was analyzed. Tumor metastasis was evaluated after intravenous injection of S. mutans in murine breast cancer hematogenous metastasis model. The results indicated that S. mutans invaded the ECs accompanied by inflammation and NF-kappa B activation. S. mutans exposure potentially disrupts endothelial integrity by decreasing vascular endothelial (VE)-cadherin expression. The migration and adhesion of tumor cells were enhanced in S. mutans-stimulated ECs. Furthermore, S. mutans-induced lung vascular inflammation promoted breast cancer cell metastasis to the lungs in vivo. The results indicate that oral bacteria promote tumor metastasis through vascular inflammation and the disruption of vascular barrier function. Improving oral hygiene in patients with cancer is of great significance in preventing postoperative pneumonia and tumor metastasis.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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