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Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr(jumbled spine and ribs)mouse

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.52.4.145

Title: Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr(jumbled spine and ribs)mouse
Authors: OKANO, Shinya Browse this author
ASANO, Atsushi Browse this author
SASAKI, Nobuya Browse this author
KON, Yasuhiro Browse this author →KAKEN DB
WATANABE, Tomomasa Browse this author
AGUI, Takashi Browse this author →KAKEN DB
Keywords: Jsr
Lfng
Uncx4.1
Issue Date: Feb-2005
Publisher: The Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 52
Issue: 4
Start Page: 145
End Page: 149
Abstract: The CKH-Jsr (jumbled spine and ribs) mouse was found as a spontaneous mutant with malformation of vertebrae, that is, a short trunk and kinky tail.We examined Lunatic Fringe (Lfng) and Uncx4.1 expression in the presomitic mesoderm (PSM) and somites of Jsr-mutant (CKH-Jsr/+) embryos to elucidate pathogenesis of the Jsr mutation. Expression pattern of Lfng in the PSM of Jsr-mutant embryos was similar to that of the normal (C57BL/6) embryos. However, expression pattern of Uncx4.1 in the somites of Jsrmutant embryos was impaired to be irregular and mosaic, suggesting that the anterior-posterior (A-P) polarity is disordered in the Jsr mutant. These results indicate that the Jsr mutation disrupts the A-P polarity of somites during the somitogenesis without altering Lfng expression pattern in the PSM.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/873
Appears in Collections:Japanese Journal of Veterinary Research > Volume 52, Number 4

Submitter: 獣医学部図書室

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