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l-Carnitine supplementation for the prevention of postoperative atrial fibrillation in aortic valve surgery
| Title: | l-Carnitine supplementation for the prevention of postoperative atrial fibrillation in aortic valve surgery |
| Authors: | Shingu, Yasushige Browse this author →KAKEN DB | | Katoh, Nobuyasu Browse this author | | Ooka, Tomonori Browse this author | | Katoh, Hiroki Browse this author | | Wakasa, Satoru Browse this author →KAKEN DB |
| Keywords: | Postoperative atrial fibrillation | | l-Carnitine | | Aortic valve surgery |
| Issue Date: | 1-Nov-2021 |
| Publisher: | Springer |
| Journal Title: | General thoracic and cardiovascular surgery |
| Volume: | 69 |
| Issue: | 11 |
| Start Page: | 1460 |
| End Page: | 1466 |
| Publisher DOI: | 10.1007/s11748-021-01616-2 |
| Abstract: | Objectives l-Carnitine, a quaternary amine, improves fatty acid metabolism in the heart and has anti-inflammatory effects. Several studies have reported the efficacy of l-carnitine for the prophylaxis of arrhythmia. We assessed the clinical effectiveness of l-carnitine in preventing postoperative atrial fibrillation (POAF) in aortic valve surgery. Methods Thirty patients who underwent aortic valve surgery were included. Fifteen patients had no prophylaxis other than conventional measures (control), while 15 patients received oral l-carnitine for 9 days (daily dose of 3 g). The incidence of POAF during 1 week after surgery was compared between the two groups. The multivariable logistic regression analysis for POAF was performed using the pre- and intraoperative parameters. Results Preoperative characteristics and operative data were comparable between the groups. The POAF rate was significantly lower in the l-carnitine group than in the control (20% and 60%, respectively; P = 0.025). l-Carnitine use was an independently negative predictor for POAF (odds ratio 0.067; 95% confidence interval 0.006-0.768). Conclusions l-Carnitine administration may have potential for the prevention of POAF in aortic valve surgery. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in General thoracic and cardiovascular surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11748-021-01616-2 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/87317 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 若狭 哲
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